Telomere-associated protein RIF1

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[5][6][7]

RIF1
Identifiers
Aliases	RIF1, replication timing regulatory factor 1
External IDs	OMIM: 608952 MGI: 1098622 HomoloGene: 41231 GeneCards: RIF1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3 Start 151,409,883 bp[1] End 151,508,013 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C1.1|2 29.98 cM Start 52,072,832 bp[2] End 52,122,383 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • chromosome, telomeric region • cell membrane • spindle • male pronucleus • female pronucleus • cell nucleus • cytoskeleton • nucleoplasm • chromosome • nuclear chromatin • condensed chromosome • nuclear body • nuclear membrane • spindle midzone • site of double-strand break Biological process • stem cell population maintenance • cell cycle • double-strand break repair via nonhomologous end joining • negative regulation of transcription from RNA polymerase II promoter • telomere maintenance • chromatin silencing at telomere • telomere maintenance in response to DNA damage • positive regulation of histone H3-K9 methylation • cellular response to DNA damage stimulus • positive regulation of isotype switching • negative regulation of double-strand break repair via homologous recombination • positive regulation of double-strand break repair via nonhomologous end joining • DNA repair • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55183	51869
Ensembl	ENSG00000080345	ENSMUSG00000036202
UniProt	Q5UIP0	Q6PR54
RefSeq (mRNA)	NM_001177663 NM_001177664 NM_001177665 NM_018151	NM_175238 NM_001355414 NM_001355415
RefSeq (protein)	NP_001171134 NP_001171135 NP_001171136 NP_060621	NP_780447 NP_001342343 NP_001342344
Location (UCSC)	Chr 2: 151.41 – 151.51 Mb	Chr 2: 52.07 – 52.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000080345 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036202 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T (September 2004). "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development. 18 (17): 2108–19. doi:10.1101/gad.1216004. PMC 515289. PMID 15342490.
6. Adams IR, McLaren A (April 2004). "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics. 229 (4): 733–44. doi:10.1002/dvdy.10471. PMID 15042697.
7. "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)".
8. Ribeyre C, Shore D (2012). "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology. 19 (3): 307–13. doi:10.1038/nsmb.2225. PMID 22343724.
9. Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA (2016-01-01). "Serial interactome capture of the human cell nucleus". Nature Communications. 7: 11212. doi:10.1038/ncomms11212. PMC 4822031. PMID 27040163.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Xu L, Blackburn EH (December 2004). "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules". The Journal of Cell Biology. 167 (5): 819–30. doi:10.1083/jcb.200408181. PMC 2172464. PMID 15583028.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.