RERE

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.[5][6][7]

RERE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQK
Identifiers
Aliases	RERE, ARG, ARP, ATN1L, DNB1, arginine-glutamic acid dipeptide repeats, NEDBEH
External IDs	OMIM: 605226 MGI: 2683486 HomoloGene: 8101 GeneCards: RERE
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 8,352,397 bp[1] End 8,848,921 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 81.34 cM Start 150,281,646 bp[2] End 150,621,966 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • sequence-specific DNA binding • DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • chromatin binding • metal ion binding • GO:0001948 protein binding • poly-glutamine tract binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription factor binding Cellular component • histone deacetylase complex • cell nucleus Biological process • chromatin remodeling • regulation of transcription, DNA-templated • dendrite morphogenesis • cerebellar Purkinje cell layer maturation • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • cerebellum development • branching morphogenesis of a nerve • cerebellar granule cell precursor proliferation • multicellular organism development • radial glia guided migration of Purkinje cell • positive regulation of transcription from RNA polymerase II promoter • NLS-bearing protein import into nucleus • transcription from RNA polymerase II promoter • negative regulation of nucleic acid-templated transcription • regulation of transcription from RNA polymerase II promoter • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	473	68703
Ensembl	ENSG00000142599	ENSMUSG00000039852
UniProt	Q9P2R6	Q80TZ9
RefSeq (mRNA)	NM_001042681 NM_001042682 NM_012102	NM_001085492
RefSeq (protein)	NP_001036146 NP_001036147 NP_036234	NP_001078961
Location (UCSC)	Chr 1: 8.35 – 8.85 Mb	Chr 4: 150.28 – 150.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

RERE has been shown to interact with ATN1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000142599 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039852 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000). "Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine". Human Molecular Genetics. 9 (9): 1433–42. doi:10.1093/hmg/9.9.1433. PMID 10814707.
6. Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM (Mar 2000). "Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP". Genomics. 64 (2): 195–202. doi:10.1006/geno.1999.6097. PMID 10729226.
7. "Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats".

Further reading

• Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC (Mar 2006). "Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors". Genes & Development. 20 (5): 525–30. doi:10.1101/gad.1393506. PMC 1410805. PMID 16481466.
• Wang L, Charroux B, Kerridge S, Tsai CC (Jun 2008). "Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates". EMBO Reports. 9 (6): 555–62. doi:10.1038/embor.2008.67. PMC 2427389. PMID 18451879.
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Oct 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Waerner T, Gardellin P, Pfizenmaier K, Weith A, Kraut N (Apr 2001). "Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis". Cell Growth & Differentiation. 12 (4): 201–10. PMID 11331249.
• Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
• Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 171–84. PMID 12107413.
• Tomarev SI, Wistow G, Raymond V, Dubois S, Malyukova I (Jun 2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Investigative Ophthalmology & Visual Science. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
• Zoltewicz JS, Stewart NJ, Leung R, Peterson AS (Jan 2004). "Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis" (PDF). Development. 131 (1): 3–14. doi:10.1242/dev.00908. PMID 14645126.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.