REPS1

RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene.[5]

REPS1
Identifiers
Aliases	REPS1, RALBP1, RALBP1 associated Eps domain containing 1, NBIA7
External IDs	OMIM: 614825 MGI: 1196373 HomoloGene: 7515 GeneCards: REPS1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.1 Start 138,903,493 bp[1] End 138,988,261 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 18,055,861 bp[2] End 18,125,155 bp[2]
Gene ontology Molecular function • calcium ion binding • SH3 domain binding • GO:0001948 protein binding • metal ion binding Cellular component • membrane • cell membrane • clathrin-coated pit • cytosol Biological process • receptor-mediated endocytosis • membrane organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85021	19707
Ensembl	ENSG00000135597	ENSMUSG00000019854
UniProt	Q96D71	O54916
RefSeq (mRNA)	NM_001128617 NM_001286611 NM_001286612 NM_031922	NM_001111065 NM_009048
RefSeq (protein)	NP_001122089 NP_001273540 NP_001273541 NP_114128	NP_001104535 NP_033074
Location (UCSC)	Chr 6: 138.9 – 138.99 Mb	Chr 10: 18.06 – 18.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135597 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019854 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: REPS1 RALBP1 associated Eps domain containing 1".

Further reading

• Cantor SB, Urano T, Feig LA (1995). "Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases". Mol. Cell. Biol. 15 (8): 4578–84. doi:10.1128/mcb.15.8.4578. PMC 230698. PMID 7623849.
• Yamaguchi A, Urano T, Goi T, Feig LA (1998). "An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1". J. Biol. Chem. 272 (50): 31230–4. doi:10.1074/jbc.272.50.31230. PMID 9395447.
• Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
• Xu J, Zhou Z, Zeng L, et al. (2002). "Cloning, expression and characterization of a novel human REPS1 gene". Biochim. Biophys. Acta. 1522 (2): 118–21. doi:10.1016/s0167-4781(01)00310-4. PMID 11750063.
• Cullis DN, Philip B, Baleja JD, Feig LA (2003). "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors". J. Biol. Chem. 277 (51): 49158–66. doi:10.1074/jbc.M206316200. PMID 12364336.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hu Y, Mivechi NF (2003). "HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200. PMID 12621024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Drake KJ, Singhal J, Yadav S, et al. (2007). "RALBP1/RLIP76 mediates multidrug resistance". Int. J. Oncol. 30 (1): 139–44. doi:10.3892/ijo.30.1.139. PMID 17143522.
• Singhal SS, Singhal J, Nair MP, et al. (2007). "Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer". Int. J. Oncol. 30 (3): 717–25. doi:10.3892/ijo.30.3.717. PMID 17273774.