RCC1

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.[5]

RCC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRCC1, CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDsOMIM: 179710 MGI: 1913989 HomoloGene: 55567 GeneCards: RCC1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p35.3Start28,505,943 bp[1]
End28,539,300 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1104

100088

Ensembl

ENSG00000180198

ENSMUSG00000028896

UniProt

P18754
Q5T081

Q8VE37

RefSeq (mRNA)

NM_001197082
NM_133878

RefSeq (protein)

NP_001184011
NP_598639

Location (UCSC)Chr 1: 28.51 – 28.54 MbChr 4: 132.33 – 132.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions

RCC1 has been shown to interact with RANBP3[6][7] and Ran (biology).[8][9][10][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000180198 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028896 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RCC1 Regulator of chromosome condensation 1".
  6. Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". The Journal of Biological Chemistry. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.
  7. Mueller L, Cordes VC, Bischoff FR, Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Letters. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251.
  8. Steggerda SM, Paschal BM (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". The Journal of Biological Chemistry. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. PMID 10811801.
  9. Renault L, Kuhlmann J, Henkel A, Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. PMID 11336674.
  10. Azuma Y, Renault L, García-Ranea JA, Valencia A, Nishimoto T, Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". Journal of Molecular Biology. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
  11. Ren M, Villamarin A, Shih A, Coutavas E, Moore MS, LoCurcio M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Molecular and Cellular Biology. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. PMC 230439. PMID 7891706.

Further reading


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