RBM7

RNA-binding motif protein 7 is a protein that in humans is encoded by the RBM7 gene.[5][6]

RBM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M8H, 5IQQ
Identifiers
Aliases	RBM7, RNA binding motif protein 7
External IDs	OMIM: 612413 MGI: 1914260 HomoloGene: 9379 GeneCards: RBM7
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 114,400,030 bp[1] End 114,414,203 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 48,488,701 bp[2] End 48,495,299 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • single-stranded RNA binding • RNA binding • GO:0001948 protein binding Cellular component • nucleoplasm • nucleolus • cell nucleus Biological process • GO:0007126 meiotic cell cycle • regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10179	67010
Ensembl	ENSG00000076053	ENSMUSG00000042396
UniProt	Q9Y580	Q9CQT2
RefSeq (mRNA)	NM_016090 NM_001286045 NM_001286046 NM_001286047 NM_001286048	NM_144948 NM_001326355 NM_001326356
RefSeq (protein)	NP_001272974 NP_001272975 NP_001272976 NP_001272977 NP_057174	NP_001313284 NP_001313285 NP_659197
Location (UCSC)	Chr 11: 114.4 – 114.41 Mb	Chr 9: 48.49 – 48.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RBM7 has been shown to interact with SF3B2[7] and SFRS3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000076053 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042396 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: RBM7 RNA binding motif protein 7".
7. Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Bugai A, Quaresma AJ, Friedel CC (Apr 2019). "P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress". Mol Cell. 74 (2): 254–267.e10. doi:10.1016/j.molcel.2019.01.033. PMC 6482433. PMID 30824372.
• Fukushima K, Satoh T, Sugihara F (Mar 2020). "Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis". Immunity. 52 (3): 542-556.e13. doi:10.1016/j.immuni.2020.02.007. PMID 32187520. Rbm7 in epithelial cells plays a critical role in the development of fibrosis by regulating ncRNA decay and thereby the production of chemokines.

External links

• RBM7 human gene location in the UCSC Genome Browser.
• RBM7 human gene details in the UCSC Genome Browser.