RBBP9

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.[5][6][7]

RBBP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QS9
Identifiers
Aliases	RBBP9, BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDs	OMIM: 602908 MGI: 1347074 HomoloGene: 4816 GeneCards: RBBP9
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.23 Start 18,486,540 bp[1] End 18,497,225 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G1 Start 144,542,265 bp[2] End 144,550,869 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • hydrolase activity Cellular component • cell nucleus • nucleoplasm • cytoplasm Biological process • regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10741	26450
Ensembl	ENSG00000089050	ENSMUSG00000027428
UniProt	O75884	O88851
RefSeq (mRNA)	NM_006606 NM_153328	NM_015754
RefSeq (protein)	NP_006597	NP_056569
Location (UCSC)	Chr 20: 18.49 – 18.5 Mb	Chr 2: 144.54 – 144.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.[7]

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000089050 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027428 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.
6. Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 252–3. doi:10.1159/000015304. PMID 10449909.
7. "Entrez Gene: RBBP9 retinoblastoma binding protein 9".

Further reading

• Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics. 40 (7–8): 273–82. doi:10.1023/A:1019886918029. PMID 12296629.
• Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein". Journal of Human Genetics. 48 (4): 164–9. doi:10.1007/s10038-002-0001-3. PMID 12730717.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.