RASSF2

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[5][6][7]

RASSF2
Identifiers
Aliases	RASSF2, CENP-34, RASFADIN, Ras association domain family member 2
External IDs	OMIM: 609492 MGI: 2442060 HomoloGene: 22840 GeneCards: RASSF2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 4,780,023 bp[1] End 4,823,608 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F2 Start 131,989,415 bp[2] End 132,030,258 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase activity Cellular component • cytoplasm • cell nucleus • chromosome, centromeric region • condensed chromosome kinetochore • kinetochore • chromosome • nucleoplasm • Golgi apparatus • cytosol • cell membrane • macromolecular complex Biological process • positive regulation of JNK cascade • positive regulation of protein autophosphorylation • skeletal system development • regulation of osteoclast differentiation • negative regulation of peptidyl-serine phosphorylation • regulation of osteoblast differentiation • regulation of NIK/NF-kappaB signaling • homeostasis of number of cells • bone remodeling • ossification • negative regulation of NIK/NF-kappaB signaling • epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade • positive regulation of apoptotic process • signal transduction • positive regulation of protein kinase activity • protein stabilization • cell cycle • protein phosphorylation • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9770	215653
Ensembl	ENSG00000101265	ENSMUSG00000027339
UniProt	P50749	Q8BMS9
RefSeq (mRNA)	NM_014737 NM_170774	NM_175445 NM_001362866
RefSeq (protein)	NP_055552 NP_739580	NP_780654 NP_001349795
Location (UCSC)	Chr 20: 4.78 – 4.82 Mb	Chr 2: 131.99 – 132.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[7]

Interactions

RASSF2 has been shown to interact with KRAS.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000101265 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027339 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
6. Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.
7. "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
8. Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Comincini S, Castiglioni BM, Foti GM, et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. 12 (2): 150–6. doi:10.1007/s003350010239. PMID 11210185.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vos MD, Ellis CA, Elam C, et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. PMID 12732644.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fujita H, Fukuhara S, Sakurai A, et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
• Akino K, Toyota M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69. doi:10.1053/j.gastro.2005.03.051. PMID 16012945.
• Endoh M, Tamura G, Honda T, et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. 93 (12): 1395–9. doi:10.1038/sj.bjc.6602854. PMC 2361541. PMID 16265349.
• Zhang Z, Sun D, Van do N, et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. 120 (1): 32–8. doi:10.1002/ijc.22185. hdl:10616/38128. PMID 17013896.
• Park HW, Kang HC, Kim IJ, et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. 120 (1): 7–12. doi:10.1002/ijc.22276. PMID 17013898.
• Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. 367 (5): 1294–311. doi:10.1016/j.jmb.2007.01.026. PMID 17320110.
• Kaira K, Sunaga N, Tomizawa Y, et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. 31 (1): 169–73. doi:10.3892/ijo.31.1.169. PMID 17549418.