RASGRF2

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.[4]

RASGRF2
Identifiers
Aliases	RASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDs	OMIM: 606614 MGI: 109137 HomoloGene: 2169 GeneCards: RASGRF2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 80,960,363 bp[1] End 81,230,162 bp[1]
Gene ontology Molecular function • calmodulin binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • endoplasmic reticulum membrane • membrane • cell membrane • endoplasmic reticulum Biological process • regulation of Ras protein signal transduction • MAPK cascade • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • small GTPase mediated signal transduction • response to endoplasmic reticulum stress • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5924	19418
Ensembl	ENSG00000113319	n/a
UniProt	O14827	P70392
RefSeq (mRNA)	NM_006909	NM_009027
RefSeq (protein)	NP_008840	NP_033053
Location (UCSC)	Chr 5: 80.96 – 81.23 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][4]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000113319 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
5. "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.

Further reading

• Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". Genomics. 39 (1): 118–20. doi:10.1006/geno.1996.4484. PMID 9027497.
• Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras". Mol. Cell. Biol. 17 (3): 1396–406. doi:10.1128/mcb.17.3.1396. PMC 231864. PMID 9032266.
• Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways". Curr. Biol. 8 (16): 935–8. doi:10.1016/S0960-9822(07)00376-4. PMID 9707409.
• Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf". Mol. Cell. Biol. 19 (7): 4611–22. doi:10.1128/mcb.19.7.4611. PMC 84259. PMID 10373510.
• Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways". Eur. J. Biochem. 269 (2): 638–49. doi:10.1046/j.0014-2956.2001.02694.x. PMID 11856323.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors" (PDF). Mol. Cell. Biol. 24 (4): 1516–30. doi:10.1128/MCB.24.4.1516-1530.2004. PMC 344182. PMID 14749369.
• Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer". Oncol. Rep. 15 (5): 1281–5. doi:10.3892/or.15.5.1281. PMID 16596198.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses". Mol. Cell. Biol. 27 (23): 8127–42. doi:10.1128/MCB.00912-07. PMC 2169177. PMID 17923690.