RASGEF1A

RasGEF domain family, member 1A is a protein that in humans is encoded by the RASGEF1A gene.[5]

RASGEF1A
Identifiers
Aliases	RASGEF1A, CG4853, RasGEF domain family member 1A
External IDs	OMIM: 614531 MGI: 1917977 HomoloGene: 17067 GeneCards: RASGEF1A
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.21 Start 43,194,535 bp[1] End 43,266,919 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 118,011,438 bp[2] End 118,091,546 bp[2]
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytosol Biological process • positive regulation of Ras protein signal transduction • cell migration • MAPK cascade • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221002	70727
Ensembl	ENSG00000198915	ENSMUSG00000030134
UniProt	Q8N9B8	n/a
RefSeq (mRNA)	NM_001282862 NM_145313	NM_027526 NM_001316749 NM_001362103 NM_001362104 NM_001362105
RefSeq (protein)	NP_001269791 NP_660356	n/a
Location (UCSC)	Chr 10: 43.19 – 43.27 Mb	Chr 6: 118.01 – 118.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000198915 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030134 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RasGEF domain family, member 1A".

Further reading

• Ura K, Obama K, Satoh S, Sakai Y, Nakamura Y, Furukawa Y (Nov 2006). "Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma". Clinical Cancer Research. 12 (22): 6611–6. doi:10.1158/1078-0432.CCR-06-0783. PMID 17121879.
• Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A (Apr 2005). "A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk". Nature. 434 (7035): 857–63. doi:10.1038/nature03467. PMID 15829955.
• Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK (Feb 2009). "Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2694–9. doi:10.1073/pnas.0809630105. PMC 2650328. PMID 19196962.
• Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH (Aug 2009). "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange". The FEBS Journal. 276 (16): 4607–16. doi:10.1111/j.1742-4658.2009.07166.x. hdl:11693/22668. PMID 19645719.
• Burzynski GM, Nolte IM, Bronda A, Bos KK, Osinga J, Plaza Menacho I, Twigt B, Maas S, Brooks AS, Verheij JB, Buys CH, Hofstra RM (May 2005). "Identifying candidate Hirschsprung disease-associated RET variants". American Journal of Human Genetics. 76 (5): 850–8. doi:10.1086/429589. PMC 1199373. PMID 15759212.