RAI2

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.[5][6][7]

RAI2
Identifiers
Aliases	RAI2, retinoic acid induced 2
External IDs	OMIM: 300217 MGI: 1344378 HomoloGene: 11034 GeneCards: RAI2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.13 Start 17,800,049 bp[1] End 17,861,337 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 161,717,069 bp[2] End 161,779,496 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • cellular component Biological process • embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10742	24004
Ensembl	ENSG00000131831	ENSMUSG00000043518
UniProt	Q9Y5P3	Q9QVY8
RefSeq (mRNA)	NM_001172732 NM_001172739 NM_001172743 NM_021785	NM_001103367 NM_198409
RefSeq (protein)	NP_001166203 NP_001166210 NP_001166214 NP_068557 NP_001166210.1 NP_001166214.1 NP_068557.3	NP_001096837 NP_940801
Location (UCSC)	Chr X: 17.8 – 17.86 Mb	Chr X: 161.72 – 161.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This article is about the protein. For the Italian television channel, see Rai 2.

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043518 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics. 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
6. Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet. 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933.
7. "Entrez Gene: RAI2 retinoic acid induced 2".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.