RAI14

Ankycorbin is a protein that in humans is encoded by the RAI14 gene.[5][6] Ankycorbin has been associated with the cortical actin cytoskeleton structures in terminal web, cell-cell adhesion sites as well as stress fibres.[7]

RAI14
Identifiers
Aliases	RAI14, NORPEG, RAI13, retinoic acid induced 14
External IDs	OMIM: 606586 MGI: 1922896 HomoloGene: 9199 GeneCards: RAI14
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 34,656,328 bp[1] End 34,832,612 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 10,568,969 bp[2] End 10,714,624 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell cortex • cytoskeleton • cell nucleus • fibrillar center • cytoplasm • cytosol • cell junction Biological process • spermatogenesis • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26064	75646
Ensembl	ENSG00000039560	ENSMUSG00000022246
UniProt	Q9P0K7	Q9EP71
RefSeq (mRNA)	NM_001145520 NM_001145521 NM_001145522 NM_001145523 NM_001145525 NM_015577	NM_001166408 NM_030690 NM_001356534
RefSeq (protein)	NP_001138992 NP_001138993 NP_001138994 NP_001138995 NP_001138997 NP_056392	NP_001159880 NP_109615 NP_001343463
Location (UCSC)	Chr 5: 34.66 – 34.83 Mb	Chr 15: 10.57 – 10.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000039560 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022246 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kutty RK, Kutty G, Samuel W, Duncan T, Bridges CC, El-Sherbeeny A, Nagineni CN, Smith SB, Wiggert B (May 2001). "Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid". J Biol Chem. 276 (4): 2831–40. doi:10.1074/jbc.M007421200. PMID 11042181.
6. "Entrez Gene: RAI14 retinoic acid induced 14".
7. Peng YF, Mandai K, Sakisaka T, Okabe N, Yamamoto Y, Yokoyama S, Mizoguchi A, Shiozaki H, Monden M, Takai Y (December 2000). "Ankycorbin: a novel actin cytoskeleton-associated protein". Genes Cells. 5 (12): 1001–8. doi:10.1046/j.1365-2443.2000.00381.x. PMID 11168586.

Further reading

• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Yuan W, Zheng Y, Huo R, Lu L, Huang XY, Yin LL, Li JM, Zhou ZM, Sha JH (September 2005). "Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes". Asian J. Androl. 7 (3): 277–88. doi:10.1111/j.1745-7262.2005.00040.x. PMID 16110356.
• Kutty RK, Chen S, Samuel W, Vijayasarathy C, Duncan T, Tsai JY, Fariss RN, Carper D, Jaworski C, Wiggert B (July 2006). "Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein". Biochem. Biophys. Res. Commun. 345 (4): 1333–41. doi:10.1016/j.bbrc.2006.04.184. PMID 16729964.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.