RAB4A

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.[5]

RAB4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAB4A, HRES-1, HRES-1/RAB4, HRES1, RAB4, member RAS oncogene family
External IDsOMIM: 179511 MGI: 105069 HomoloGene: 101538 GeneCards: RAB4A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.13Start229,271,062 bp[1]
End229,305,894 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5867

19341

Ensembl

ENSG00000168118

ENSMUSG00000019478

UniProt

P20338

P56371

RefSeq (mRNA)

NM_001271998
NM_004578

NM_009003

RefSeq (protein)

NP_001258927
NP_004569
NP_004569.2

NP_033029

Location (UCSC)Chr 1: 229.27 – 229.31 MbChr 8: 123.81 – 123.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAB4A has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000168118 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019478 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RAB4A RAB4A, member RAS oncogene family".
  6. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic. 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
  7. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (Jul 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Molecular and Cellular Biology. 23 (14): 4892–900. doi:10.1128/mcb.23.14.4892-4900.2003. PMC 162221. PMID 12832475.
  8. Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
  9. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117.
  10. Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.

Further reading

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