RAB3B

RAB3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DZ8
Identifiers
Aliases	RAB3B, member RAS oncogene family
External IDs	OMIM: 179510 MGI: 1917158 HomoloGene: 2149 GeneCards: RAB3B
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	51,990,700 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	108,943,324 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • GDP binding; • GTP binding; • myosin V binding; • GO:0001948 protein binding; • GTP-dependent protein binding; • GTPase activity;
Cellular component	• cytoplasm; • vesicle; • cytosol; • membrane; • synaptic vesicle; • cell membrane; • secretory granule; • perinuclear region of cytoplasm; • extracellular exosome; • anchored component of synaptic vesicle membrane; • endosome; • Golgi apparatus; • dopaminergic synapse;
Biological process	• antigen processing and presentation; • positive regulation of dopamine uptake involved in synaptic transmission; • peptidyl-cysteine methylation; • regulation of exocytosis; • regulation of vesicle size; • protein transport; • transport; • intracellular protein transport; • vesicle docking involved in exocytosis; • protein secretion; • Rab protein signal transduction; • protein localization to plasma membrane; • regulation of synaptic vesicle cycle;
	Sources:Amigo / QuickGO
Orthologs
	5865
	69908
	ENSG00000169213
	ENSMUSG00000003411
	P20337
	Q9CZT8
	NM_002867
	NM_023537
	NP_002858
	NP_076026
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.[5]

Interactions

RAB3B has been shown to interact with RPH3A.[6][7]

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References

GRCh38: Ensembl release 89: ENSG00000169213 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003411 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: RAB3B RAB3B, member RAS oncogene family".
Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.

Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (February 1991). "Chromosome assignment of four RAS-related RAB genes". Human Genetics. 86 (4): 350–4. doi:10.1007/BF00201831. PMID 1999336.
Zahraoui A, Touchot N, Chardin P, Tavitian A (July 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". The Journal of Biological Chemistry. 264 (21): 12394–401. PMID 2501306.
Weber E, Berta G, Tousson A, St John P, Green MW, Gopalokrishnan U, Jilling T, Sorscher EJ, Elton TS, Abrahamson DR (May 1994). "Expression and polarized targeting of a rab3 isoform in epithelial cells". The Journal of Cell Biology. 125 (3): 583–94. doi:10.1083/jcb.125.3.583. PMC 2119989. PMID 8175882.
Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.
Regazzi R, Ravazzola M, Iezzi M, Lang J, Zahraoui A, Andereggen E, Morel P, Takai Y, Wollheim CB (September 1996). "Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells". Journal of Cell Science. 109 ( Pt 9) (9): 2265–73. PMID 8886977.
Sidhu RS, Bhullar RP (December 2001). "Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin". Biochemical and Biophysical Research Communications. 289 (5): 1039–43. doi:10.1006/bbrc.2001.6113. PMID 11741295.
van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE (February 2002). "Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells". Developmental Cell. 2 (2): 219–28. doi:10.1016/S1534-5807(02)00115-6. PMID 11832247.
Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S, Sasaki T (August 2003). "Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane". Biochemical and Biophysical Research Communications. 308 (2): 270–5. doi:10.1016/S0006-291X(03)01358-5. PMID 12901864.
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169213 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003411 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAB3B RAB3B, member RAS oncogene family".

[pmid12578829-6] Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.

[pmid8636125-7] Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". The Journal of Biological Chemistry. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.

RAB3B

Interactions

References

Further reading