RAB38

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.[5][6]

RAB38
Identifiers
Aliases	RAB38, NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDs	OMIM: 606281 MGI: 1919683 HomoloGene: 21353 GeneCards: RAB38
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.2 Start 88,113,251 bp[1] End 88,175,443 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D3|7 49.19 cM Start 88,430,273 bp[2] End 88,491,572 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • AP-2 adaptor complex binding • nucleotide binding • BLOC-2 complex binding • GTP binding • GTP-dependent protein binding • GO:0001948 protein binding • AP-3 adaptor complex binding • AP-1 adaptor complex binding • GTPase activity Cellular component • cytoplasm • vesicle • phagocytic vesicle membrane • Golgi apparatus • membrane • melanosome • cell membrane • early endosome • phagocytic vesicle • endoplasmic reticulum • early endosome lumen • cytoplasmic vesicle • lysosome • mitochondrion • ER-mitochondrion membrane contact site • cytosol • melanosome membrane • trans-Golgi network Biological process • protein localization to membrane • platelet dense granule organization • organelle organization • phagosome acidification • endosome to melanosome transport • protein transport • melanosome assembly • mitochondrion organization • vesicle-mediated transport • small GTPase mediated signal transduction • post-translational modification • positive regulation of phosphatidylcholine biosynthetic process • intracellular protein transport • Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23682	72433
Ensembl	ENSG00000123892	ENSMUSG00000030559
UniProt	P57729	Q8QZZ8
RefSeq (mRNA)	NM_022337	NM_028238
RefSeq (protein)	NP_071732 NP_071732.1	NP_082514
Location (UCSC)	Chr 11: 88.11 – 88.18 Mb	Chr 7: 88.43 – 88.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

In melanocytic cells RAB38 gene expression may be regulated by MITF.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
6. "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.