RAB21

Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene.[5][6][7][8]

RAB21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YZT, 1YZU, 1Z08, 1Z0I, 2OT3
Identifiers
Aliases	RAB21, member RAS oncogene family
External IDs	OMIM: 612398 MGI: 894308 HomoloGene: 8991 GeneCards: RAB21
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.1 Start 71,754,863 bp[1] End 71,800,286 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 115,287,084 bp[2] End 115,315,594 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GDP binding • GTP binding • GO:0001948 protein binding • GTPase activity Cellular component • endosome • Golgi apparatus • endoplasmic reticulum membrane • membrane • focal adhesion • vesicle membrane • Golgi membrane • Golgi cisterna membrane • trans-Golgi network • endoplasmic reticulum • neuron projection • cytoplasmic side of plasma membrane • cytoplasmic side of early endosome membrane • cleavage furrow • extracellular exosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • axon cytoplasm • cytosol • early endosome membrane • early endosome • synapse Biological process • positive regulation of receptor-mediated endocytosis • regulation of axon extension • anterograde axonal transport • regulation of exocytosis • positive regulation of dendrite morphogenesis • protein transport • positive regulation of early endosome to late endosome transport • transport • intracellular protein transport • Rab protein signal transduction • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23011	216344
Ensembl	ENSG00000080371	ENSMUSG00000020132
UniProt	Q9UL25	P35282
RefSeq (mRNA)	NM_014999	NM_024454
RefSeq (protein)	NP_055814	NP_077774
Location (UCSC)	Chr 12: 71.75 – 71.8 Mb	Chr 10: 115.29 – 115.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000080371 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020132 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Opdam FJ, Kamps G, Croes H, van Bokhoven H, Ginsel LA, Fransen JA (Oct 2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur J Cell Biol. 79 (5): 308–16. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
6. Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
7. Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (Jun 2006). "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins". J Cell Biol. 173 (5): 767–80. doi:10.1083/jcb.200509019. PMC 2063892. PMID 16754960.
8. "Entrez Gene: RAB21 RAB21, member RAS oncogene family".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.