QKI

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.[5][6]

QKI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesQKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
External IDsOMIM: 609590 MGI: 97837 HomoloGene: 11059 GeneCards: QKI
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q26Start163,414,000 bp[1]
End163,578,592 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9444

19317

Ensembl

ENSG00000112531

ENSMUSG00000062078

UniProt

Q96PU8

Q9QYS9

RefSeq (mRNA)

NM_001301085
NM_006775
NM_206853
NM_206854
NM_206855

NM_001159516
NM_001159517
NM_021881

RefSeq (protein)

NP_001288014
NP_006766
NP_996735
NP_996736
NP_996737

NP_001152988
NP_001152989
NP_068681

Location (UCSC)Chr 6: 163.41 – 163.58 MbChr 17: 10.2 – 10.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[7] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .[8] Two more new members are KHDRBS3[9] and KHDRBS2.[10]

The QKI gene is implicated as being important in schizophrenia,[11][12] and QKI controls translation of many oligodendrocyte-related genes.

References

  1. GRCh38: Ensembl release 89: ENSG00000112531 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062078 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)".
  6. Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011. PMID 10535969.
  7. Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. doi:10.1016/S0168-9525(97)01269-9. PMID 9433137.
  8. Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. doi:10.1128/MCB.18.8.4863. PMC 109071. PMID 9671495.
  9. Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. doi:10.1093/hmg/8.6.959. PMID 10332027.
  10. Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. doi:10.1023/A:1021246109101. PMID 12549823.
  11. Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365. PMID 16641098.
  12. Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.

Further reading


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