Pulmonary atypical adenomatous hyperplasia

Atypical adenomatous hyperplasia (AAH) is a hyperplastic lesion of the epithelial lining of pulmonary alveoli.

Tumorigenesis

A multi-step carcinogenesis hypothesis suggests a progression from atypical adenomatous hyperplasia (AAH) through bronchioalveolar carcinoma (BAC) to invasive adenocarcinoma (AC), but to date this has not been formally demonstrated.[1]

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References

Bettio, D; Cariboni, U; Venci, A; Valente, M; Spaggiari, P; Alloisio, M (2012). "Cytogenetic findings in lung cancer that illuminate its biological history from adenomatous hyperplasia to bronchioalveolar carcinoma to adenocarcinoma: A case report". Experimental and Therapeutic Medicine. 4 (6): 1032–1034. doi:10.3892/etm.2012.725. PMC 3494121. PMID 23226769.

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[1] Bettio, D; Cariboni, U; Venci, A; Valente, M; Spaggiari, P; Alloisio, M (2012). "Cytogenetic findings in lung cancer that illuminate its biological history from adenomatous hyperplasia to bronchioalveolar carcinoma to adenocarcinoma: A case report". Experimental and Therapeutic Medicine. 4 (6): 1032–1034. doi:10.3892/etm.2012.725. PMC 3494121. PMID 23226769.