Pseudohyperaldosteronism

Pseudohyperaldosteronism (also pseudoaldosteronism) is a medical condition that mimics hyperaldosteronism.[1] Like hyperaldosteronism, it produces hypertension associated with low plasma renin activity, and metabolic alkalosis associated with hypokalemia. Unlike hyperaldosteronism, it involves aldosterone levels that are normal or low (hypoaldosteronism).

Pseudohyperaldosteronism
Other namesPseudohyperaldosteronism type 1
This condition is inherited in an autosomal dominant manner

Presentation

This condition is characterized by hypertension, kaliuresis and reduced plasma renin.

Causes

This condition has several known causes, dietary and genetic. Dietary causes include the chronic excessive ingestion of licorice.[2] Licorice inhibits the 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2) enzyme resulting in inappropriate stimulation of the mineralocorticoid receptor by cortisol.

Genetic causes include Liddle's syndrome.[3]

Diagnosis

Treatment
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See also

References
  1. Armanini D, Calò L, Semplicini A (June 2003). "Pseudohyperaldosteronism: pathogenetic mechanisms". Crit Rev Clin Lab Sci. 40 (3): 295–335. doi:10.1080/713609355. PMID 12892318.
  2. Sigurjonsdottir HA, Axelson M, Johannsson G, Manhem K, Nyström E, Wallerstedt S (2006). "The liquorice effect on the RAAS differs between the genders". Blood Press. 15 (3): 169–72. doi:10.1080/08037050600593060. PMID 16864159.
  3. Takeuchi K, Abe K, Sato M, et al. (February 1989). "Plasma aldosterone level in a female case of pseudohyperaldosteronism (Liddle's syndrome)". Endocrinol. Jpn. 36 (1): 167–73. doi:10.1507/endocrj1954.36.167. PMID 2659310.
Classification
External resources


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