Promega

Promega Corporation is a Madison, Wisconsin-based manufacturer of enzymes and other products for biotechnology and molecular biology with a portfolio covering the fields of genomics, protein analysis and expression, cellular analysis, drug discovery and genetic identity.[1]

Promega
Formerly
Biotec
Private
IndustryBiotechnology
Founded1978
Headquarters
Madison, Wisconsin
,
United States
Key people
William A. Linton Chairman and CEO
RevenueApproaching $450 million USD (2019)
Number of employees
1601 worldwide (2019)
Websitewww.promega.com www.promegaconnections.com

History

Promega Corporation was founded by Bill Linton in 1978 to provide restriction enzymes for biotechnology.[2] The company now offers more than 4,000 life science products used by scientists, researchers and life science and pharmaceutical companies. Promega has 1,601 employees. Revenue is approaching $450 million (USD) in 2019. [3]

The privately held company has branch offices in 16 countries and more than 50 global distributors serving 100 countries.[4] Promega Corporation also established the first biotechnology joint venture in China (Sino-American Biotechnology Co. in 1985).[5]

The company has developed an on-site stocking system, which uses radio frequency identification (RFID) linked to the Internet to track and manage remote inventory. This resulted in the spin-off company Terso Solutions that specializes in the design and manufacturing of small RFID storage units.[6]

In February 2020, it was reported by Foreign Policy that Promega had sold equipment to the Xinjiang Production and Construction Corps.[7]

Product areas and technologies

Genomics

The company's portfolio began with products for genomics researchers and now includes cloning systems, luciferase reporters, and amplification products as well as the original restriction and modifying enzymes. The portfolio of amplification products includes the GoTaq family of polymerases, buffers and the Plexor quantitative PCR system. [8]

Genetic identity and forensics

The company is one of two main suppliers of systems for genetic identification based on DNA analysis using short tandem repeats (STRs).[9] Promega was the first company to provide kits for STR analysis of single loci.[9] Along with Applied Biosystems, Promega participated with the FBI and other crime labs in validating STR loci that would eventually be selected as the core loci for the Combined DNA Index System (CODIS), used for forensic DNA testing in North America. [10]

The Promega PowerPlex STR systems were the first commercially available systems for STR analysis that contained all of the CODIS loci.[9]

Proteomics

Promega was an early supplier in the cell-free protein synthesis field and is continuing to develop its portfolio in this area.[11]

Cellular analysis and drug discovery

Promega offers a range of products for cell biology and drug discovery, many of which are built upon bioluminescence technology. Assays for drug discovery are used globally and include biochemical and cell-based assays. In 2010, Promega launched a custom assay services business for biologics and small molecule drug development. [12]

Integrated platforms

The company's bioluminescence assays, DNA and RNA purification chemistries, and HaloTag technologies integrate with the high-throughput automated systems found in many laboratories. Some of this integration has occurred through collaboration with instrument manufacturers.

The company also sells their own Maxwell RSC and Maxwell RSC 48 Systems, bench-top automated purification systems for low and middle throughput research and diagnostic laboratories.[13]

Promega GloMax Luminometers are supplied with preinstalled protocols that allow researchers to perform multiplex bioluminescent assays. The luminometers with injection systems are available for use with dual-reporter assays like the Dual-Luciferase systems.

The Y-Chromosome Deletion Detection System from Promega also carries the CE Mark for use as an in vitro diagnostic device in the European Union.[14]

Footnotes
  1. "Company Information". Archived from the original on January 2, 2013. Retrieved January 3, 2013.
  2. "Promega eNotes - Feature". Archived from the original on July 4, 2008. Retrieved November 11, 2008.
  3. "Building on success: Promega corp. has blossomed, and it's not done growing yet". Archived from the original on September 5, 2012. Retrieved January 3, 2013.
  4. "Company Information". Archived from the original on January 2, 2013. Retrieved January 3, 2013.
  5. "madison.com". Retrieved November 11, 2008.
  6. 2005 Report: Promega spins off RFID unit. The Capital Times. November 15. Business, 8B. Retrieved on July 7, 2008.
  7. Batke, Jessica; Ohlberg, Mareike (February 19, 2020). "China's Biosecurity State in Xinjiang Is Powered by Western Tech". Foreign Policy. Archived from the original on February 28, 2020. Retrieved 2020-02-28.
  8. "Products". www.promega.com. Archived from the original on 2019-06-06. Retrieved 2019-07-03.
  9. Amplification on-line training course at DNA.gov Archived 2008-08-30 at the Wayback Machine
  10. "What is CODIS?". National Institute of Justice. Archived from the original on 2019-07-03. Retrieved 2019-07-03.
  11. Zhao KQ, Hurst R, Slater MR, Bulleit RF (December 2007). "Functional protein expression from a DNA based wheat germ cell-free system". J. Struct. Funct. Genomics. 8 (4): 199–208. doi:10.1007/s10969-007-9035-2. PMID 18034374.
  12. "Promega introduces custom assay services for biologics and small molecule drug discovery".
  13. (2008) Promega gets CE Mark for DNA purification system. GenomeWeb Daily May 29. (accessed July 18, 2008)
  14. "Y Chromosome Deletion Detection System, Version 2.0". www.promega.com. Archived from the original on 2019-07-03. Retrieved 2019-07-03.
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