PreQ1-II riboswitch

PreQ1-II riboswitches form a class of riboswitches that specifically bind pre-queuosine1 (PreQ1), a precursor of the modified nucleoside queuosine.[1] They are found in certain species of Streptococcus and Lactococcus, and were originally identified as a conserved RNA secondary structure called the "COG4708 motif".[2] All known members of this riboswitch class appear to control members of COG4708 genes. These genes are predicted to encode membrane-bound proteins and have been proposed to be a transporter of preQ1, or a related metabolite, based on their association with preQ1-binding riboswitches.[1] PreQ1-II riboswitches have no apparent similarities in sequence or structure to preQ1-I riboswitches, a previously discovered class of preQ1-binding riboswitches. PreQ1 thus joins S-adenosylmethionine as the second metabolite to be found that is the ligand of more than one riboswitch class.

Consensus secondary structure of PreQ1-II riboswitches. Layout is similar to that used in previously published depictions.[2][1]
preQ1-II (pre queuosine) riboswitch
Predicted secondary structure and sequence conservation of preQ1-II
Identifiers
SymbolpreQ1-II
Alt. SymbolsCOG4708
RfamRF01054
Other data
RNA typeCis-reg; riboswitch
Domain(s)Bacteria
SO0005836
PDB structuresPDBe

References
  1. Meyer MM, Roth A, Chervin SM, Garcia GA, Breaker RR (2008). "Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria". RNA. 14 (4): 685–695. doi:10.1261/rna.937308. PMC 2271366. PMID 18305186.
  2. Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
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