Pompilidotoxin

Pompilidotoxin is a toxin from the venom of spider wasps that slows the inactivation of Na+channels.

Etymology

Pompilidotoxin is named after the pompilidae wasp family (commonly called spider wasps).

Sources

α-Pompilidotoxin (α-PMTX) can be extracted from the venom of a solitary wasp, Anoplius samariensis. β-Pompilidotoxin (β-PMTX) originates from the venom of another wasp, Batozonellus maculifrons.[1]

Chemistry

Structure α-PMTX consists of 13 amino acid residues with the sequence Arg-Ile-Lys-Ile-Gly-Leu-Phe-Gln-Asp-Leu-Ser-Lys-Leu-NH2.

Replacement of the lysine residue at position 12 of α-PMTX with arginine results in β-PMTX.[1]

Homology α-PMTX has no structural homology with other toxins. It lacks disulfide bonds which are known to be present in other toxins acting on sodium channels, such as sea anemone toxins or scorpion toxins.[2]

Target

Both α- and β-PMTX slow the inactivation of neuronal sodium channels (but not heart sodium channels), possibly by binding to the neurotoxin receptor site 3 on the extracellular surface of the sodium channel.[2]

β-PMTX has higher potency than α-PMTX.[1]

Mode of action

By slowing down the inactivation of sodium channels, PMTXs can potentiate synaptic transmission in the lobster neuromuscular endplate.[1]

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References
  1. Konno K, Hisada M, Itagaki Y, Naoki H, Kawai N, Miwa A, Yasuhara T, Takayama H (1998). "Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms". Biochem Biophys Res Commun. 250 (3): 612–6. doi:10.1006/bbrc.1998.9299. PMID 9784394.
  2. Sahara Y, Gotoh M, Konno K, Miwa A, Tsubokawa H, Robinson HP, Kawai N (2000). "A new class of neurotoxin from wasp venom slows inactivation of sodium current". Eur J Neurosci. 12 (6): 1961–70. doi:10.1046/j.1460-9568.2000.00084.x. PMID 10886337.
  • Kawai N, Konno K (2004). "Molecular determinants of two neurotoxins that regulate sodium current inactivation in rat hippocampal neurons". Neurosci. Lett. 361 (1–3): 44–6. doi:10.1016/j.neulet.2004.01.006. PMID 15135889.
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