Plunc

Palate, lung, and nasal epithelium clone protein[5] (PLUNC) is a gene encoding a secretory protein. It is also called Secretory protein in upper respiratory tracts (SPURT). In humans, it is encoded by the BPIFA1 gene, previously called PLUNC.[6][7]

BPIFA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KEG, 4KGH, 4KGO, 4N4X, 5I7K, 5I7J, 5I7L
Identifiers
Aliases	BPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDs	OMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: BPIFA1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 33,235,995 bp[1] End 33,243,311 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,142,880 bp[2] End 154,149,219 bp[2]
Gene ontology Molecular function • lipid binding • GO:0001948 protein binding • molecular function Cellular component • extracellular region • extracellular Biological process • negative regulation of single-species biofilm formation in or on host organism • multicellular organismal water homeostasis • defense response to bacterium • regulation of sodium ion transmembrane transport • antibacterial humoral response • immune system process • innate immune system • antimicrobial humoral response • regulation of liquid surface tension • immune response in nasopharyngeal-associated lymphoid tissue • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51297	18843
Ensembl	ENSG00000198183	ENSMUSG00000027483
UniProt	Q9NP55	P97361
RefSeq (mRNA)	NM_001243193 NM_016583 NM_130852	NM_011126
RefSeq (protein)	NP_001230122 NP_057667 NP_570913	NP_035256
Location (UCSC)	Chr 20: 33.24 – 33.24 Mb	Chr 2: 154.14 – 154.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the airways and nasopharyngeal regions. Plunc inhibits the epithelial sodium channel (ENaC),[8] and also has anti-microbial functions.[9] As such, plunc is believed to play a role in innate immune defense in the airways. PLUNC's ability to regulate ENaC is pH-sensitive and fails in acidic cystic fibrosis airways.[10] Thus, defective PLUNC1 function is thought to contribute to the development of lung pathology in cystic fibrosis patients.

It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer.[11]

References

1. GRCh38: Ensembl release 89: ENSG00000198183 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027483 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ghafouri, B. (2003). "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31 (4): 810–4. doi:10.1042/bst0310810. PMID 12887311.
6. Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
7. Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A (Feb 2001). "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer". International Journal of Cancer. 91 (4): 433–7. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B. PMID 11251963.
8. Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R (Jul 2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage". Proceedings of the National Academy of Sciences of the United States of America. 106 (27): 11412–7. Bibcode:2009PNAS..10611412G. doi:10.1073/pnas.0903609106. PMC 2708735. PMID 19541605.
9. 6
10. Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R (Oct 2013). "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways". Proceedings of the National Academy of Sciences of the United States of America. 110 (40): 15973–8. Bibcode:2013PNAS..11015973G. doi:10.1073/pnas.1311999110. PMC 3791714. PMID 24043776.
11. "Entrez Gene: PLUNC".

Further reading

• Zhang B, Nie X, Xiao B, Xiang J, Shen S, Gong J, Zhou M, Zhu S, Zhou J, Qian J, Lu H, He X, Li X, Hu G, Li G (Sep 2003). "Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray". Genes, Chromosomes & Cancer. 38 (1): 80–90. doi:10.1002/gcc.10247. PMID 12874788.
• Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R (Jul 2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage". Proceedings of the National Academy of Sciences of the United States of America. 106 (27): 11412–7. Bibcode:2009PNAS..10611412G. doi:10.1073/pnas.0903609106. PMC 2708735. PMID 19541605.
• Zhang BC, Zhu SG, Xiang JJ, Zhou M, Nie XM, Xiao BY, Li XL, Li GY (May 2003). "[Analysis of splicing variants in NASG 3'UTR, down-regulated in nasopharyngeal carcinoma, and its expression in multiple cancer tissues]". AI Zheng = Aizheng = Chinese Journal of Cancer. 22 (5): 477–80. PMID 12753706.
• Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC (Apr 2009). "Determination of genetic predisposition to patent ductus arteriosus in preterm infants". Pediatrics. 123 (4): 1116–23. doi:10.1542/peds.2008-0313. PMC 2734952. PMID 19336370.
• Bryborn M, Halldén C, Säll T, Cardell LO (Feb 2010). "CLC- a novel susceptibility gene for allergic rhinitis?". Allergy. 65 (2): 220–8. doi:10.1111/j.1398-9995.2009.02141.x. PMID 19650845.
• Cheng M, Chen Y, Yu X, Tian Z, Wei H (2008). "Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer". BMC Cancer. 8: 156. doi:10.1186/1471-2407-8-156. PMC 2424066. PMID 18513434.
• Zhou HD, Li GY, Yang YX, Li XL, Sheng SR, Zhang WL, Zhao J (Apr 2006). "Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carcinoma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain". Molecular Immunology. 43 (11): 1864–71. doi:10.1016/j.molimm.2005.10.021. PMID 16364440.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Zhou HD, Fan SQ, Zhao J, Huang DH, Zhou M, Liu HY, Zeng ZY, Yang YX, Huang H, Li XL, Shen SR, Li GY (Mar 2006). "Tissue distribution of the secretory protein, SPLUNC1, in the human fetus". Histochemistry and Cell Biology. 125 (3): 315–24. doi:10.1007/s00418-005-0070-4. PMID 16195890.
• Sentani K, Oue N, Sakamoto N, Arihiro K, Aoyagi K, Sasaki H, Yasui W (Apr 2008). "Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach". Modern Pathology. 21 (4): 464–75. doi:10.1038/modpathol.3801050. PMID 18204429.
• Bingle CD, Gorr SU (Nov 2004). "Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family". The International Journal of Biochemistry & Cell Biology. 36 (11): 2144–52. doi:10.1016/j.biocel.2004.05.002. PMID 15313462.
• Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL (Feb 2004). "Purification and characterization of PLUNC from human tracheobronchial secretions". American Journal of Respiratory Cell and Molecular Biology. 30 (2): 184–92. doi:10.1165/rcmb.2003-0142OC. PMID 12920053.
• He Y, Ding YQ, Huang ZX, Yao KT (Jun 2007). "[Association of the coding region single nucleotide polymorphisms in PLUNC gene with nasopharyngeal carcinoma]". Zhonghua Yi Xue Za Zhi. 87 (22): 1553–5. PMID 17785110.
• Wang WB, Cui YG, Yao SY (Feb 2008). "[Message RNA expression of LUNX, CK19 and CEA genes in NSCLC with micrometastasis in lymph nodes]". Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]. 30 (2): 121–4. PMID 18646695.
• Bartlett JA, Hicks BJ, Schlomann JM, Ramachandran S, Nauseef WM, McCray PB (May 2008). "PLUNC is a secreted product of neutrophil granules". Journal of Leukocyte Biology. 83 (5): 1201–6. doi:10.1189/jlb.0507302. PMID 18245229.
• Zhou HD, Li XL, Li GY, Zhou M, Liu HY, Yang YX, Deng T, Ma J, Sheng SR (Feb 2008). "Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus". Molecular and Cellular Biochemistry. 309 (1–2): 191–7. doi:10.1007/s11010-007-9659-3. PMID 18049866.
• Ghafouri B, Kihlström E, Tagesson C, Lindahl M (Jun 2004). "PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide". Biochimica et Biophysica Acta. 1699 (1–2): 57–63. doi:10.1016/j.bbapap.2004.01.001. PMID 15158712.
• Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA, Bingle CD (2007). "Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis". Respiratory Research. 8: 79. doi:10.1186/1465-9921-8-79. PMC 2203987. PMID 17988392.

External links

• PLUNC+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.