Plakophilin-3

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[5][6]

PKP3
Identifiers
Aliases	PKP3, plakophilin 3
External IDs	OMIM: 605561 MGI: 1891830 HomoloGene: 5200 GeneCards: PKP3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 392,614 bp[1] End 404,908 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,078,218 bp[2] End 141,090,510 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • alpha-catenin binding • cell adhesion molecule binding • cadherin binding involved in cell-cell adhesion • RNA binding • GO:0001948 protein binding • enzyme binding • translation regulator activity • cadherin binding Cellular component • desmosome • cell nucleus • intercellular junction • cornified envelope • nucleoplasm • cell membrane • cell junction • messenger ribonucleoprotein complex • cytoplasm Biological process • desmosome assembly • cell adhesion • keratinization • cornification • regulation of translation • positive regulation of gene expression • negative regulation of mRNA catabolic process • protein localization to plasma membrane • cell-cell adhesion • cell-cell junction assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11187	56460
Ensembl	ENSG00000184363	ENSMUSG00000054065
UniProt	Q9Y446	Q9QY23
RefSeq (mRNA)	NM_007183 NM_001303029	NM_001162924 NM_019762
RefSeq (protein)	NP_001289958 NP_009114	NP_001156396 NP_062736
Location (UCSC)	Chr 11: 0.39 – 0.4 Mb	Chr 7: 141.08 – 141.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[6]

Interactions

PKP3 has been shown to interact with:

• DSC3,[7]
• DSG1,[7]
• DSG2[7] and
• DSG3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000184363 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054065 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
6. "Entrez Gene: PKP3 plakophilin 3".
7. Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. hdl:1854/LU-210987. PMC 2172904. PMID 12707304.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bonné S, van Hengel J, Nollet F, Kools P, van Roy F (1999). "Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells". J. Cell Sci. 112 (14): 2265–76. PMID 10381383.
• Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H (2000). "Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis". J. Cell Sci. 113 (13): 2471–83. PMID 10852826.
• Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
• Papagerakis S, Shabana AH, Depondt J, Gehanno P, Forest N (2003). "Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters". Hum. Pathol. 34 (6): 565–72. doi:10.1016/S0046-8177(03)00174-6. PMID 12827610.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke WW (2006). "Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules". Mol. Biol. Cell. 17 (3): 1388–98. doi:10.1091/mbc.E05-08-0708. PMC 1382326. PMID 16407409.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonné S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007). "The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression". FEBS Lett. 581 (8): 1617–24. doi:10.1016/j.febslet.2007.03.026. PMC 2938730. PMID 17391671.