Phosphoprotein

A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes).[1]

Biological function

The phosphorylation of proteins is a major regulatory mechanism in cells.[2][3]

Clinical significance

Phosphoproteins have been proposed as biomarkers for breast cancer.[4][2]

gollark: A panic/abort/crash/whatever is controlled and fairly safe.
gollark: Buffer overflows and stuff are more likely to lead to some sort of code execution issue.
gollark: Yes.
gollark: I mean, if your program just crashes, it's better than buffer-overflowing or something.
gollark: But the new bugs would probably be safer ones.

See also

References
  1. Keyword - Phosphoprotein
  2. Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
  3. Cozzone AJ (1988). "Protein phosphorylation in prokaryotes". Annu. Rev. Microbiol. 42: 97–125. doi:10.1146/annurev.mi.42.100188.000525. PMID 2849375.
  4. Liquid Biopsy Could Get Boost from Phosphoproteins. 2017
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