Phospholipase A-2-activating protein

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.[4][5][6]

PLAA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifiers
Aliases	PLAA, DOA1, PLA2P, PLAP, phospholipase A2 activating protein, NDMSBA
External IDs	OMIM: 603873 MGI: 104810 HomoloGene: 3138 GeneCards: PLAA
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 26,903,372 bp[1] End 26,947,242 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • phospholipase A2 activator activity • ubiquitin binding Cellular component • extracellular exosome • cytoplasm • cell nucleus • synapse • cell junction Biological process • phospholipid metabolic process • inflammatory response • signal transduction • ubiquitin recycling • proteasome-mediated ubiquitin-dependent protein catabolic process • macroautophagy • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • cellular response to lipopolysaccharide • negative regulation of protein K63-linked ubiquitination • positive regulation of synaptic vesicle recycling • positive regulation of dendrite extension • positive regulation of neuron migration • prostaglandin metabolic process • multicellular organism development • nervous system development • positive regulation of phospholipase A2 activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9373	18786
Ensembl	ENSG00000137055	n/a
UniProt	Q9Y263	P27612
RefSeq (mRNA)	NM_001031689 NM_004253 NM_001321546	NM_172695
RefSeq (protein)	NP_001026859 NP_001308475	NP_766283
Location (UCSC)	Chr 9: 26.9 – 26.95 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000137055 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID 9931468.
5. Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID 10644453.
6. "Entrez Gene: PLAA phospholipase A2-activating protein".

Further reading

• Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. doi:10.1073/pnas.88.12.5418. PMC 51884. PMID 2052621.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ruiz A, Nadal M, Puig S, Estivill X (1999). "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region". Gene. 239 (1): 155–61. doi:10.1016/S0378-1119(99)00354-6. PMID 10571045.
• Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMC 99970. PMID 11689694.
• Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases". J. Biol. Chem. 277 (25): 22992–9. doi:10.1074/jbc.M202298200. PMID 11937510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Koumanov K, Momchilova A, Wolf C (2004). "Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2". Cell Biol. Int. 27 (10): 871–7. doi:10.1016/S1065-6995(03)00176-8. PMID 14499668.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.