Phosphatidylethanolamine binding protein 1

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.[5][6]

PEBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BD9, 1BEH, 2L7W, 2QYQ
Identifiers
Aliases	PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1
External IDs	OMIM: 604591 MGI: 1344408 HomoloGene: 37637 GeneCards: PEBP1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,136,124 bp[1] End 118,145,584 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 56.88 cM Start 117,282,654 bp[2] End 117,287,625 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • lipid binding • nucleotide binding • protein kinase binding • phosphatidylethanolamine binding • serine-type endopeptidase inhibitor activity • ATP binding • enzyme binding • peptidase inhibitor activity • RNA binding • receptor binding • mitogen-activated protein kinase binding Cellular component • cytoplasm • cytosol • cell nucleus • extracellular exosome • extracellular • mitochondrion • mitochondrial outer membrane • Golgi apparatus • synaptic vesicle • cell surface • neuronal cell body • myelin • axon terminus • apical part of cell Biological process • MAPK cascade • negative regulation of peptidase activity • negative regulation of endopeptidase activity • regulation of neurotransmitter levels • regulation of the force of heart contraction • response to oxidative stress • aging • response to heat • response to wounding • response to toxic substance • response to organonitrogen compound • response to activity • hippocampus development • negative regulation of MAPK cascade • positive regulation of cAMP-mediated signaling • response to ethanol • positive regulation of mitotic nuclear division • sperm capacitation • response to corticosterone • response to cAMP • response to calcium ion • positive regulation of acetylcholine metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5037	23980
Ensembl	ENSG00000089220	ENSMUSG00000032959
UniProt	P30086	P70296
RefSeq (mRNA)	NM_002567	NM_018858
RefSeq (protein)	NP_002558	NP_061346
Location (UCSC)	Chr 12: 118.14 – 118.15 Mb	Chr 5: 117.28 – 117.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Phosphatidylethanolamine binding protein 1 has been shown to interact with:

• C-Raf,[7]
• MAP2K1,[7] and
• MAPK1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000089220 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032959 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Park S, Yeung ML, Beach S, Shields JM, Yeung KC (May 2005). "RKIP downregulates B-Raf kinase activity in melanoma cancer cells". Oncogene. 24 (21): 3535–40. doi:10.1038/sj.onc.1208435. PMID 15782137.
6. "Entrez Gene: PEBP1 phosphatidylethanolamine binding protein 1".
7. Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (May 2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/mcb.20.9.3079-3085.2000. PMC 85596. PMID 10757792.

Further reading

• Schoentgen F, Jollès P (1995). "From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site". FEBS Lett. 369 (1): 22–6. doi:10.1016/0014-5793(95)00376-K. PMID 7641877.
• Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, Matsukawa N (2000). "Hippocampal cholinergic neurostimulating peptides (HCNP)". Prog. Neurobiol. 60 (1): 37–83. doi:10.1016/S0301-0082(99)00021-0. PMID 10622376.
• Odabaei G, Chatterjee D, Jazirehi AR, Goodglick L, Yeung K, Bonavida B (2004). Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. Adv. Cancer Res. Advances in Cancer Research. 91. pp. 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 9780120066919. PMID 15327891.
• Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Tohdoh N, Tojo S, Agui H, Ojika K (1995). "Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein". Brain Res. Mol. Brain Res. 30 (2): 381–4. doi:10.1016/0169-328X(95)00029-R. PMID 7637590.
• Seddiqi N, Bollengier F, Alliel PM, Périn JP, Bonnet F, Bucquoy S, Jollès P, Schoentgen F (1994). "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues". J. Mol. Evol. 39 (6): 655–60. doi:10.1007/BF00160411. PMID 7807553.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hori N, Chae KS, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (1994). "A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein". Gene. 140 (2): 293–4. doi:10.1016/0378-1119(94)90562-2. PMID 8144042.
• Moore C, Perry AC, Love S, Hall L (1996). "Sequence analysis and immunolocalisation of phosphatidylethanolamine binding protein (PBP) in human brain tissue". Brain Res. Mol. Brain Res. 37 (1–2): 74–8. doi:10.1016/0169-328X(95)00285-Z. PMID 8738137.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Banfield MJ, Barker JJ, Perry AC, Brady RL (1998). "Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction". Structure. 6 (10): 1245–54. doi:10.1016/S0969-2126(98)00125-7. PMID 9782050.
• Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W (1999). "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP" (PDF). Nature. 401 (6749): 173–7. doi:10.1038/43686. PMID 10490027.
• Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792.
• Hengst U, Albrecht H, Hess D, Monard D (2001). "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors". J. Biol. Chem. 276 (1): 535–40. doi:10.1074/jbc.M002524200. PMID 11034991.
• Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
• Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, Okamoto T, Ueda R, Ojika K (2002). "Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease". J. Neuropathol. Exp. Neurol. 61 (2): 176–85. doi:10.1093/jnen/61.2.176. PMID 11853019.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.