Phosphatidic acid phosphatase 2c

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[5][6][7]

PLPP2
Identifiers
Aliases	PLPP2, LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDs	OMIM: 607126 MGI: 1354945 HomoloGene: 2752 GeneCards: PLPP2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 281,040 bp[1] End 291,403 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 79,526,430 bp[2] End 79,533,796 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphoprotein phosphatase activity • GO:0001948 protein binding • lipid phosphatase activity • hydrolase activity • sphingosine-1-phosphate phosphatase activity • phosphatidate phosphatase activity • phosphatase activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • phospholipid metabolic process • sphingolipid biosynthetic process • phospholipid dephosphorylation • signal transduction • protein dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8612	50784
Ensembl	ENSG00000141934	ENSMUSG00000052151
UniProt	O43688	Q9DAX2
RefSeq (mRNA)	NM_003712 NM_177526 NM_177543	NM_015817 NM_001302389 NM_001302390 NM_001302442
RefSeq (protein)	NP_003703 NP_803545 NP_808211	NP_001289318 NP_001289319 NP_001289371 NP_056632
Location (UCSC)	Chr 19: 0.28 – 0.29 Mb	Chr 10: 79.53 – 79.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141934 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052151 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.
6. Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309.
7. "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Further reading

• Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID 12471011.
• Morris KE, Schang LM, Brindley DN (2006). "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts". J. Biol. Chem. 281 (14): 9297–306. doi:10.1074/jbc.M511710200. PMID 16467304.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang N, Sundberg JP, Gridley T (2000). "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile". Genesis. 27 (4): 137–40. doi:10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4. PMID 10992322.
• Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–67. doi:10.1074/jbc.273.34.22059. PMID 9705349.