Phosida

The PHOsphorylation SIte DAtabase PHOSIDA integrates thousands of high-confidence in vivo phosphosites identified in various species on the basis of mass spectrometry technology. For each phosphosite, PHOSIDA lists matching kinase motifs, predicted secondary structures, conservation patterns, and its dynamic regulation upon stimulus or other treatments such as kinase inhibition, for example. It includes phosphoproteomes of various organisms ranging from eukaryotes such as human and yeast to bacteria such as Escherichia coli and Lactococcus lactis. Even the phosphoproteome of an archaean organism, namely Halobacterium salinarium, is available. The integration of phosphoproteomes identified in organisms, which cover the phylogenetic tree representatively, enables to examine phosphorylation events from a global point of view including conservation and evolutionary preservation in time.[1]

PHOSIDA
Content
Descriptionposttranslational modification database.
Contact
Research centerMax-Planck-Institute for Biochemistry
LaboratoryDepartment of Proteomics and Signal Transduction
AuthorsFlorian Gnad
Primary citationGnad & al. (2011)[1]
Release date2009
Access
Websitehttp://www.phosida.com

Moreover, PHOSIDA also predicts phosphosites on the basis of support vector machines.

References

  1. Gnad, Florian; Gunawardena Jeremy; Mann Matthias (Jan 2011). "PHOSIDA 2011: the posttranslational modification database". Nucleic Acids Res. 39: D253-60. doi:10.1093/nar/gkq1159. PMC 3013726. PMID 21081558.
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