Phorbol-12-myristate-13-acetate-induced protein 1

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[3][4][5]

PMAIP1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDsOMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q21.32Start59,899,948 bp[1]
End59,904,306 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5366

n/a

Ensembl

ENSG00000141682

n/a

UniProt

Q13794

n/a

RefSeq (mRNA)

NM_021127

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 18: 59.9 – 59.9 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

gollark: WEB APPLICATION FIREWALL
gollark: yes.
gollark: I'm sure nobody or palaiologos or someone will eventually complain that C is not an unfathomable nightmarish hellscape and its wild unsafety is fine because just don't make mistakes.
gollark: The actual LLVM *language* isn't, even if it's implemented in it.
gollark: C is older and people program in it *directly* sometimes.

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000141682 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol. 64 (10): 4632–9. PMC 247947. PMID 2398525.
  4. Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012.
  5. "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1".
  6. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576.
  7. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
  8. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. PMID 10807576.
  9. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11): 1294–305. doi:10.1101/gad.1304105. PMC 1142553. PMID 15901672.

Further reading

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