Peptide PHI

Peptide PHI (or peptide histidine isoleucine) is a peptide which functions as a hormone.

Rat Peptide histidine isoleucine (PHI) structure

Peptide histidine isoleucine (PHI) is part of family that plays a vital role in the cell growth rate such as in the intestine as well as in brain.[1] While PHI and other peptides belonging to the same family have somewhat similar chemical and biological function, however PHI has different structure from them. It contains composition contains 27 amino acid intestinal peptide.[2] PHI functions specifically function in the G protein signaling pathway.

It also plays a role in the regulation of prolactin in humans.[3] PHI functions through G protein, which is a transmembrane protein that causes the cascade phosphorylation. It located throughout the entire length of intestine while PHI is mostly concentrated in the colon region.[4]

References
  1. Tatemoto, Kazuhiko; Mutt, Viktor (June 1980). "Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides". Nature. 285 (5764): 417–418. doi:10.1038/285417a0. ISSN 1476-4687.
  2. Lelièvre, Vincent; Pineau, Nicolas; Du, Joanna; Wen, Chia-Hui; Nguyen, Thinh; Janet, Thierry; Muller, Jean-Marc; Waschek, James A. (1998-07-31). "Differential Effects of Peptide Histidine Isoleucine (PHI) and Related Peptides on Stimulation and Suppression of Neuroblastoma Cell Proliferation: A NOVEL VIP-INDEPENDENT ACTION OF PHI VIA MAP KINASE". Journal of Biological Chemistry. 273 (31): 19685–19690. doi:10.1074/jbc.273.31.19685. ISSN 0021-9258.
  3. Kulick R, Chaiseha Y, Kang S, Rozenboim I, El Halawani M (2005). "The relative importance of vasoactive intestinal peptide and peptide histidine isoleucine as physiological regulators of prolactin in the domestic turkey". Gen Comp Endocrinol. 142 (3): 267–273. doi:10.1016/j.ygcen.2004.12.024. PMID 15935152.
  4. Yiangou, Y.; Christofides, N.D.; Blank, M.A.; Yanaihara, N.; Tatemoto, K.; Bishop, A.E.; Polak, J.M.; Bloom, S.R. (September 1985). "Molecular forms of peptide histidine isoleucine-like immunoreactivity in the gastrointestinal tract". Gastroenterology. 89 (3): 516–524. doi:10.1016/0016-5085(85)90445-7. ISSN 0016-5085.


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