Pendetide
Pendetide (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K).[1]
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Names | |
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IUPAC name
N6-[N-[2-[[2-[Bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl]-N2-(N-glycyl-L-tyrosyl)-L-lysine | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C31H47N7O14 | |
Molar mass | 741.318 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
Use
The following monoclonal antibodies are linked to pendetide to chelate a radionuclide, indium-111. The antibodies selectively bind to certain tumour cells, and the radioactivity is then used for imaging of the tumours.
- Indium (111In) capromab pendetide (prostate cancer)
- Indium (111In) satumomab pendetide (other cancer types)
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gollark: https://drive.google.com/drive/folders/1OL0D5ujUX3Eyd3xcSbeXaEWe0nRmT5U1?usp=sharing↑ mgollark, March edition
References
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