Palmatine

palmatine
Names
	IUPAC name 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
	Other names Berbericinine
Identifiers
CAS Number	3486-67-7;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL274189;
ChemSpider	5224;
PubChem CID	19009;
UNII	G50C034217;
CompTox Dashboard (EPA)	DTXSID9048065 ;
	InChI InChI=1/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3 Key: AEQDJSLRWYMAQI-UHFFFAOYAT;
	SMILES O(c1c4c(ccc1OC)CC3c2c(cc(OC)c(OC)c2)CCN3C4)C;
Properties
Chemical formula	C21H22NO4+
Molar mass	352.4083 g/mol
Density	1.23 g/cm3
Boiling point	482.9 °C (901.2 °F; 756.0 K) at 760 mmHg
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Palmatine is a protoberberine alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis/Coptis Chinensis and Corydalis yanhusuo.[1]

It is the major component of the protoberberine extract from Enantia chlorantha.[2]

It has been studied for its potential use in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.[3] This compound also has weak in vitro activity against flavivirus.[4]

References

Wang YM, Zhao LB, Lin SL, Dong SS, An DK (1989). "[Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC]". Yao Xue Xue Bao = Acta Pharmaceutica Sinica (in Chinese). 24 (4): 275–9. PMID 2816389.
Virtanen P., Njimi T.,Ekotto Mengata D.:Clinical trials of hepatitis cure with protoberberine alkaloids of Enantia Chlorantha (abstract) Eur.J.Clin.Pharmacol.36: A123, 1989b
Bhadra K, Kumar GS (January 2010). "Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design". Medicinal Research Reviews. 31: 821–862. doi:10.1002/med.20202. PMID 20077560.
Jia F., Zou G., Fan J., Yuan Z."Identification of palmatine as an inhibitor of West Nile virus" Archives of Virology 2010 155:8 (1325-1329)

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