Pagetoid

Pagetoid is a term used in dermatology to refer to "upward spreading" of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below. Squamous cell carcinoma, melanoma in situ, Pagetoid [[Bowen's disease], ocular sebaceous carcinoma and other carcinomas can all display pagetoid growth.

Pagetoid (seen peripherally to a melanoma in situ.

The term Pagetoid (Paget-like) is derived from the Extramammary Paget's disease, wherein the large tumour cells are arranged singly or in small clusters within the epidermis and its appendages. These cells are distinguished by a clear halo from the surrounding epithelial cells and a finely granular cytoplasm.[1] This proliferation of cells in the epidermis is responsible for the 'buckshot scatter' pattern.[2] This is a typical feature of superficial spreading type of Malignant Melanoma.

References
  1. Kumar V, Abbas AK, Fausto N. Robbins and Cotran's Pathologic Basis of Disease.Elsevier.1069
  2. "Dermatopathological terminology - DermNet New Zealand". www.dermnetnz.org.
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