PURG

Purine-rich element binding protein G is a protein that in humans is encoded by the PURG gene.[5]

PURG
Identifiers
Aliases	PURG, PURG-A, PURG-B, purine-rich element binding protein G, purine rich element binding protein G, PURGA, PURGB
External IDs	OMIM: 618041 MGI: 1922279 HomoloGene: 22747 GeneCards: PURG
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 30,995,802 bp[1] End 31,033,715 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A3 Start 33,386,325 bp[2] End 33,417,467 bp[2]
Gene ontology Molecular function • DNA binding • RNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • double-stranded DNA binding • purine-rich negative regulatory element binding • sequence-specific DNA binding Cellular component • cell nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29942	75029
Ensembl	ENSG00000172733	ENSMUSG00000049184
UniProt	Q9UJV8	Q8R4E6
RefSeq (mRNA)	NM_001015508 NM_013357 NM_001323311 NM_001323312	NM_001098233 NM_152821 NM_001382855
RefSeq (protein)	NP_001015508 NP_001310240 NP_001310241 NP_037489	NP_001091703 NP_690034 NP_001369784
Location (UCSC)	Chr 8: 31 – 31.03 Mb	Chr 8: 33.39 – 33.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A (PURA). The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000172733 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049184 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Purine-rich element binding protein G". Retrieved 2015-12-27.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.