PUGNAc

PUGNAc is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases. It was long thought that increased levels of O-GlcNAc in human cells lead to Type II diabetes. O-GlcNAc levels were artificially raised with PUGNAc, which inhibits O-GlcNAcase, a beta-exo-N-acetylhexosaminidase which cleaves beta-O-linked-N-acetylglucosamine residues from glycoproteins. As a result of this inhibition, a type II diabetic phenotype was observed. Recent pharmacological studies using a more selective O-GlcNAcase inhibitor did not see this effect. However, genetic manipulation of O-GlcNAc levels is consistent with the effects observed by PUGNAc, namely insulin resistance upon elevation of O-GlcNAc levels.

PUGNAc
Clinical data
Pregnancy
category
  • ?
Routes of
administration
Oral
Identifiers
CAS Number
PubChem CID
Chemical and physical data
FormulaC15H19N3O7
Molar mass353.33 g·mol−1
  (verify)

Fictional references

PUGNAc was used by Michael Scofield in the television series Prison Break to keep his blood sugar level high to appear diabetic.

gollark: *Somehow* AutoBotRobot is using 100% CPU.
gollark: It turns out I am its master now, not <@319753218592866315>.
gollark: Okay, I now know.
gollark: I don't know why it considers me an admin though, will have to look into that.
gollark: I had to configure autorestart.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.