PTPLAD1

Protein tyrosine phosphatase-like protein PTPLAD1 is an enzyme that in humans is encoded by the PTPLAD1 gene.[5][6][7]

HACD3
Identifiers
Aliases	HACD3, B-IND1, BIND1, HSPC121, PTPLAD1, 3-hydroxyacyl-CoA dehydratase 3
External IDs	OMIM: 615940 MGI: 1889341 HomoloGene: 9494 GeneCards: HACD3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,530,418 bp[1] End 65,578,349 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,986,983 bp[2] End 65,021,693 bp[2]
Gene ontology Molecular function • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001948 protein binding • lyase activity • enzyme binding • 3-hydroxyacyl-CoA dehydratase activity • 3-hydroxy-lignoceroyl-CoA dehydratase activity • 3-hydroxy-behenoyl-CoA dehydratase activity • 3-hydroxy-arachidoyl-CoA dehydratase activity • very-long-chain 3-hydroxyacyl-CoA dehydratase activity Cellular component • integral component of membrane • nuclear membrane • endoplasmic reticulum membrane • membrane • focal adhesion • endoplasmic reticulum • mitochondrion • cytosol • integral component of endoplasmic reticulum membrane Biological process • activation of JUN kinase activity • positive regulation by virus of viral protein levels in host cell • lipid metabolism • small GTPase mediated signal transduction • fatty acid metabolic process • JNK cascade • fatty acid biosynthetic process • very long-chain fatty acid biosynthetic process • Rho protein signal transduction • fatty acid elongation • positive regulation of viral genome replication • Rac protein signal transduction • I-kappaB kinase/NF-kappaB signaling • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51495	57874
Ensembl	ENSG00000074696	ENSMUSG00000033629
UniProt	Q9P035	Q8K2C9
RefSeq (mRNA)	NM_016395	NM_021345
RefSeq (protein)	NP_057479	NP_067320
Location (UCSC)	Chr 15: 65.53 – 65.58 Mb	Chr 9: 64.99 – 65.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000074696 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033629 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Courilleau D, Chastre E, Sabbah M, Redeuilh G, Atfi A, Mester J (Jul 2000). "B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts". J Biol Chem. 275 (23): 17344–8. doi:10.1074/jbc.M000887200. PMID 10747961.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
7. "Entrez Gene: PTPLAD1 protein tyrosine phosphatase-like A domain containing 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Sabbah M, Saucier C, Redeuilh G (2006). "Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors". Gene. 374: 128–33. doi:10.1016/j.gene.2006.01.022. PMID 16516406.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.