PTBP2

PTBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQ1, 2MJU, 4CQ1
Identifiers
Aliases	PTBP2, PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	OMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	96,823,738 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	119,784,466 bp[2]
Gene ontology
Molecular function	• mRNA binding; • pre-mRNA binding; • nucleic acid binding; • RNA binding;
Cellular component	• growth cone; • spliceosomal complex; • neuronal cell body; • cell nucleus;
Biological process	• mRNA splice site selection; • cerebellum development; • mRNA processing; • RNA splicing; • spinal cord development; • regulation of neural precursor cell proliferation; • negative regulation of RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	58155
	56195
	ENSG00000117569
	ENSMUSG00000028134
	Q9UKA9
	Q91Z31
NM_001300985; NM_001300986; NM_001300987; NM_001300988; NM_001300989;
	NM_001300990; NM_021190
	NM_019550; NM_001310711
NP_001287914; NP_001287915; NP_001287916; NP_001287917; NP_001287918;
	NP_001287919; NP_067013
	NP_001297640; NP_062423
	Wikidata
View/Edit Human	View/Edit Mouse

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.[5][6]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.[6]

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References

GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
"Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11003644-5] Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.

[entrez-6] "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".