PRSS2

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.[5]

PRSS2
Identifiers
Aliases	PRSS2, TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2
External IDs	OMIM: 601564 MGI: 102759 HomoloGene: 122141 GeneCards: PRSS2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 142,760,398 bp[1] End 142,774,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 41,521,787 bp[2] End 41,525,079 bp[2]
Gene ontology Molecular function • calcium ion binding • peptidase activity • GO:0001948 protein binding • hydrolase activity • metal ion binding • serine-type endopeptidase activity • serine-type peptidase activity • metalloendopeptidase activity Cellular component • extracellular matrix • extracellular region • extracellular • azurophil granule lumen Biological process • collagen catabolic process • digestion • positive regulation of cell growth • extracellular matrix disassembly • proteolysis • positive regulation of cell adhesion • antimicrobial humoral response • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5645	22072
Ensembl	ENSG00000282049 ENSG00000275896	ENSMUSG00000057163
UniProt	P07478	P07146
RefSeq (mRNA)	NM_001303414 NM_002770	NM_009430
RefSeq (protein)	NP_001290343 NP_002761	NP_033456
Location (UCSC)	Chr 7: 142.76 – 142.77 Mb	Chr 6: 41.52 – 41.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

References

1. ENSG00000275896 GRCh38: Ensembl release 89: ENSG00000282049, ENSG00000275896 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057163 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Protease, serine, 2 (trypsin 2)".

Further reading

• Williams SJ, Gotley DC, Antalis TM (July 2001). "Human trypsinogen in colorectal cancer". International Journal of Cancer. 93 (1): 67–73. doi:10.1002/ijc.1304. PMID 11391623.
• Mayumi T, Inui K, Maetani I, Yokoe M, Sakamoto T, Yoshida M, Ko S, Hirata K, Takada T (August 2012). "Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis". Pancreas. 41 (6): 869–75. doi:10.1097/MPA.0b013e3182480ab7. PMID 22481290.
• "PRSS1-Related Hereditary Pancreatitis". 1993. PMID 22379635. Cite journal requires |journal= (help)
• Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". Journal of Proteome Research. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.
• Vilen ST, Suojanen J, Salas F, Risteli J, Ylipalosaari M, Itkonen O, Koistinen H, Baumann M, Stenman UH, Sorsa T, Salo T, Nyberg P (October 2012). "Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP". Cancer Investigation. 30 (8): 583–92. doi:10.3109/07357907.2012.716467. PMID 22909050.
• Lempinen M, Isoniemi H, Mäkisalo H, Nordin A, Halme L, Arola J, Höckerstedt K, Stenman UH (November 2007). "Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures". Journal of Hepatology. 47 (5): 677–83. doi:10.1016/j.jhep.2007.05.017. PMID 17640760.
• Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (June 2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". Journal of Neurovirology. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
• Baptista AM, Jonson PH, Hough E, Petersen SB (September 1998). "The origin of trypsin: evidence for multiple gene duplications in trypsins". Journal of Molecular Evolution. 47 (3): 353–62. doi:10.1007/PL00006393. PMID 9732462.
• Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L (June 2010). "Identification of pancreatic juice proteins as biomarkers of pancreatic cancer". Oncology Reports. 23 (6): 1683–92. doi:10.3892/or_00000812. PMID 20428826.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.