PRCP

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.[5][6]

This article is about the gene. For the postnominal, see Royal College of Physicians.

PRCP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2Z
Identifiers
Aliases	PRCP, HUMPCP, PCP, prolylcarboxypeptidase
External IDs	OMIM: 176785 MGI: 1919711 HomoloGene: 55867 GeneCards: PRCP
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 82,822,936 bp[1] End 82,970,584 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 92,874,470 bp[2] End 92,934,583 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • serine-type carboxypeptidase activity • peptidase activity • GO:0001948 protein binding • carboxypeptidase activity • serine-type peptidase activity • hydrolase activity • dipeptidyl-peptidase activity Cellular component • basal part of cell • cell membrane • lysosome • extracellular exosome • azurophil granule membrane • ficolin-1-rich granule membrane Biological process • blood coagulation, intrinsic pathway • glucose homeostasis • regulation of reactive oxygen species metabolic process • energy homeostasis • plasma kallikrein-kinin cascade • regulation of thyroid hormone mediated signaling pathway • neutrophil degranulation • negative regulation of systemic arterial blood pressure • proteolysis • regulation of blood vessel endothelial cell migration • angiogenesis involved in wound healing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5547	72461
Ensembl	ENSG00000137509	ENSMUSG00000061119
UniProt	P42785	Q7TMR0
RefSeq (mRNA)	NM_005040 NM_199418 NM_001319214	NM_028243
RefSeq (protein)	NP_001306143 NP_005031 NP_955450	NP_082519
Location (UCSC)	Chr 11: 82.82 – 82.97 Mb	Chr 7: 92.87 – 92.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137509 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tan F, Morris PW, Skidgel RA, Erdos EG (Sep 1993). "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families". J Biol Chem. 268 (22): 16631–8. PMID 8344943.
6. "Entrez Gene: PRCP prolylcarboxypeptidase (angiotensinase C)".

Further reading

• Odya CE, Marinkovic DV, Hammon KJ, et al. (1978). "Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney". J. Biol. Chem. 253 (17): 5927–31. PMID 28321.
• Yang HY, Erdös EG, Chiang TS (1968). "New enzymatic route for the inactivation of angiotensin". Nature. 218 (5148): 1224–6. doi:10.1038/2181224a0. PMID 4297812.
• Jackman HL, Tan F, Schraufnagel D, et al. (1995). "Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages". Am. J. Respir. Cell Mol. Biol. 13 (2): 196–204. doi:10.1165/ajrcmb.13.2.7626287. PMID 7626287.
• Watson B, Nowak NJ, Myracle AD, et al. (1997). "The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension". Genomics. 44 (3): 365–7. doi:10.1006/geno.1997.4883. PMID 9325062.
• Shariat-Madar Z, Mahdi F, Schmaier AH (2002). "Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator". J. Biol. Chem. 277 (20): 17962–9. doi:10.1074/jbc.M106101200. PMID 11830581.
• Moreira CR, Schmaier AH, Mahdi F, et al. (2002). "Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator" (PDF). FEBS Lett. 523 (1–3): 167–70. doi:10.1016/S0014-5793(02)02980-0. PMID 12123826.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shariat-Madar Z, Mahdi F, Schmaier AH (2004). "Recombinant prolylcarboxypeptidase activates plasma prekallikrein" (PDF). Blood. 103 (12): 4554–61. doi:10.1182/blood-2003-07-2510. PMID 14996700.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Feng Y, Zhang Y, et al. (2006). "Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia". Am. J. Obstet. Gynecol. 195 (1): 162–71. doi:10.1016/j.ajog.2006.01.079. PMID 16681991.