PPP6C

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.[5][6]

PPP6C
Identifiers
Aliases	PPP6C, PP6, PP6C, protein phosphatase 6 catalytic subunit
External IDs	OMIM: 612725 MGI: 1915107 HomoloGene: 68273 GeneCards: PPP6C
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 125,146,573 bp[1] End 125,189,939 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 39,194,354 bp[2] End 39,226,451 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding • protein serine/threonine phosphatase activity Cellular component • cytoplasm • cytosol • Golgi membrane • mitochondrion Biological process • cell cycle • COPII vesicle coating • protein dephosphorylation • immune system process • innate immune system • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5537	67857
Ensembl	ENSG00000119414	ENSMUSG00000026753
UniProt	O00743	Q9CQR6
RefSeq (mRNA)	NM_001123355 NM_001123369 NM_002721	NM_024209
RefSeq (protein)	NP_001116827 NP_001116841 NP_002712	NP_077171
Location (UCSC)	Chr 9: 125.15 – 125.19 Mb	Chr 2: 39.19 – 39.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP6C has been shown to interact with IGBP1.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000119414 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026753 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (April 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.
6. "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".
7. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, et al. (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
8. Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

Further reading

• Bastians H, Ponstingl H (December 1996). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Journal of Cell Science. 109 ( Pt 12) (Pt 12): 2865–74. PMID 9013334.
• Chen J, Peterson RT, Schreiber SL (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
• Nasu-Nishimura Y, Hayashi T, Ohishi T, Okabe T, Ohwada S, Hasegawa Y, et al. (June 2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes to Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191.
• Stefansson B, Brautigan DL (August 2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". The Journal of Biological Chemistry. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
• Stefansson B, Brautigan DL (June 2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells". Cell Cycle. 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.