PPP3R2

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene.[5][6] Among its related pathways are MAPK signaling pathway[7] and GPCR pathway.[8] GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.[9]

PPP3R2
Identifiers
Aliases	PPP3R2, PPP3RL, protein phosphatase 3 regulatory subunit B, beta
External IDs	OMIM: 613821 MGI: 107171 HomoloGene: 133815 GeneCards: PPP3R2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 101,591,604 bp[1] End 101,595,021 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 49,678,747 bp[2] End 49,682,024 bp[2]
Orthologs
Species	Human	Mouse
Entrez	5535	19059
Ensembl	ENSG00000188386	ENSMUSG00000028310
UniProt	Q96LZ3	Q63811
RefSeq (mRNA)	NM_147180	NM_001004025
RefSeq (protein)	NP_671709	NP_001004025
Location (UCSC)	Chr 9: 101.59 – 101.6 Mb	Chr 4: 49.68 – 49.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000188386 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028310 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (May 2005). "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis". Mol Biol Rep. 32 (1): 41–5. doi:10.1007/s11033-004-4250-4. PMID 15865209.
6. "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform".
7. "PathCards :: MAPK signaling pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
8. "PathCards :: GPCR Pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
9. Database, GeneCards Human Gene. "PPP3R2 Gene - GeneCards | CANB2 Protein | CANB2 Antibody". www.genecards.org. Retrieved 2015-09-08.

Further reading

• Mukai H, Chang CD, Tanaka H, et al. (1991). "cDNA cloning of a novel testis-specific calcineurin B-like protein". Biochem. Biophys. Res. Commun. 179 (3): 1325–30. doi:10.1016/0006-291X(91)91718-R. PMID 1718268.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Koefoed-Nielsen PB, Karamperis N, Højskov C, et al. (2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". Transpl. Int. 19 (10): 821–7. doi:10.1111/j.1432-2277.2006.00359.x. PMID 16961774.
• Saeki M, Irie Y, Ni L, et al. (2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 (16): 11786–94. doi:10.1074/jbc.M609347200. PMID 17324936.
• Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.