PPP1R7

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.[5][6][7][8]

PPP1R7
Identifiers
Aliases	PPP1R7, SDS22, protein phosphatase 1 regulatory subunit 7
External IDs	OMIM: 602877 MGI: 1913635 HomoloGene: 2032 GeneCards: PPP1R7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,149,576 bp[1] End 241,183,652 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,342,854 bp[2] End 93,373,489 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0010576 enzyme regulator activity • GO:0001948 protein binding • protein phosphatase regulator activity Cellular component • cytoplasm • extracellular exosome • cell nucleus • chromosome Biological process • positive regulation of protein dephosphorylation • chromosome segregation • GO:0048552 regulation of catalytic activity • regulation of phosphoprotein phosphatase activity • calcium activated phospholipid scrambling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5510	66385
Ensembl	ENSG00000115685	ENSMUSG00000026275
UniProt	Q15435	Q3UM45
RefSeq (mRNA)	NM_001282409 NM_001282410 NM_001282411 NM_001282412 NM_001282413 NM_001282414 NM_002712	NM_023200
RefSeq (protein)	NP_001269338 NP_001269339 NP_001269340 NP_001269341 NP_001269342 NP_001269343 NP_002703	NP_075689
Location (UCSC)	Chr 2: 241.15 – 241.18 Mb	Chr 1: 93.34 – 93.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000115685 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026275 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett. 375 (1–2): 75–8. doi:10.1016/0014-5793(95)01180-M. PMID 7498485.
6. Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet. 10 (4): 415–23. doi:10.1038/ng0895-415. PMID 7670491.
7. Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem. 262 (1): 36–42. doi:10.1046/j.1432-1327.1999.00344.x. PMID 10231361.
8. "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

Further reading

• Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.