PPP1R2

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.[5][6][7]

PPP1R2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP1R2, IPP-2, IPP2, protein phosphatase 1 regulatory inhibitor subunit 2, PPP1R2A
External IDsOMIM: 601792 MGI: 1914099 HomoloGene: 4546 GeneCards: PPP1R2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q29Start195,514,428 bp[1]
End195,543,386 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5504

66849

Ensembl

ENSG00000184203

ENSMUSG00000047714

UniProt

P41236

Q9DCL8

RefSeq (mRNA)

NM_001291504
NM_001291505
NM_006241
NM_001316325

NM_025800

RefSeq (protein)

NP_001278433
NP_001278434
NP_001303254
NP_006232

NP_080076

Location (UCSC)Chr 3: 195.51 – 195.54 MbChr 16: 31.25 – 31.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PPP1R2 has been shown to interact with LMTK2[8] and PPP1R9B.[9]

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References
  1. GRCh38: Ensembl release 89: ENSG00000184203 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047714 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Permana PA, Mott DM (April 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics. 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
  6. Helps NR, Street AJ, Elledge SJ, Cohen PT (February 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Letters. 340 (1–2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416.
  7. "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
  8. Wang H, Brautigan DL (December 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". The Journal of Biological Chemistry. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
  9. Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". The Journal of Biological Chemistry. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.

Further reading
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