POU2F3

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.[5][6]

POU2F3
Identifiers
Aliases	POU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3
External IDs	OMIM: 607394 MGI: 102565 HomoloGene: 7898 GeneCards: POU2F3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 120,236,640 bp[1] End 120,319,945 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.1|9 24.21 cM Start 43,123,939 bp[2] End 43,210,369 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • epidermis development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25833	18988
Ensembl	ENSG00000137709	ENSMUSG00000032015
UniProt	Q9UKI9	P31362
RefSeq (mRNA)	NM_001244682 NM_014352	NM_011139
RefSeq (protein)	NP_001231611 NP_055167	n/a
Location (UCSC)	Chr 11: 120.24 – 120.32 Mb	Chr 9: 43.12 – 43.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000137709 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032015 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi:10.1074/jbc.274.37.26399. PMID 10473598.
6. "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

Further reading

• Goldsborough A, et al. (1990). "Cloning and sequencing of POU-boxes expressed in mouse testis". Nucleic Acids Res. 18 (6): 1634. doi:10.1093/nar/18.6.1634. PMC 330540. PMID 1970171.
• Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMC 309074. PMID 8441607.
• Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. PMID 12624109.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines". Oncogene. 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.
• Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression". Placenta. 27 (4–5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
• Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer". Oncogene. 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.
• Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.