POPDC3

Popeye domain-containing protein 3 is a protein that in humans is encoded by the POPDC3 gene.[5][6]

POPDC3
Identifiers
Aliases	POPDC3, POP3, bA355M14.1, popeye domain containing 3, LGMDR26
External IDs	OMIM: 605824 MGI: 1930153 HomoloGene: 32540 GeneCards: POPDC3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 105,157,900 bp[1] End 105,180,014 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 23.35 cM Start 45,178,098 bp[2] End 45,318,452 bp[2]
Gene ontology Molecular function • cAMP binding • nucleotide binding • molecular function Cellular component • membrane • integral component of membrane • sarcolemma Biological process • biological process • regulation of membrane potential • heart development • skeletal muscle tissue development • striated muscle cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64208	78977
Ensembl	ENSG00000132429	ENSMUSG00000019848
UniProt	Q9HBV1	Q9ES81
RefSeq (mRNA)	NM_022361	NM_024286
RefSeq (protein)	NP_071756	NP_077248
Location (UCSC)	Chr 6: 105.16 – 105.18 Mb	Chr 10: 45.18 – 45.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000132429 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019848 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: popeye domain containing 3".
6. Andrée B, Hillemann T, Kessler-Icekson G, Schmitt-John T, Jockusch H, Arnold HH, Brand T (July 2000). "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart". Dev. Biol. 223 (2): 371–82. doi:10.1006/dbio.2000.9751. PMID 10882522.

Further reading

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sulem P, Gudbjartsson DF, Rafnar T, et al. (2009). "Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche". Nat. Genet. 41 (6): 734–8. doi:10.1038/ng.383. PMID 19448622.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.