POLR3E

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.[5][6][7]

POLR3E
Identifiers
Aliases	POLR3E, RPC5, SIN, polymerase (RNA) III subunit E, RNA polymerase III subunit E, C37
External IDs	OMIM: 617815 MGI: 1349452 HomoloGene: 14052 GeneCards: POLR3E
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 22,297,375 bp[1] End 22,335,101 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 120,917,744 bp[2] End 120,947,432 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • RNA polymerase III activity Cellular component • DNA-directed RNA polymerase III complex • cytosol • cell nucleus • nucleoplasm Biological process • immune system process • defense response to virus • transcription, DNA-templated • transcription from RNA polymerase III promoter • innate immune system • positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55718	26939
Ensembl	ENSG00000284282 ENSG00000058600	ENSMUSG00000030880
UniProt	Q9NVU0	Q9CZT4
RefSeq (mRNA)	NM_001258033 NM_001258034 NM_001258035 NM_001258036 NM_018119	NM_001164096 NM_025298 NM_001379288
RefSeq (protein)	NP_001244962 NP_001244963 NP_001244964 NP_001244965 NP_060589	NP_001157568 NP_079574 NP_001366217
Location (UCSC)	Chr 16: 22.3 – 22.34 Mb	Chr 7: 120.92 – 120.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLR3E has been shown to interact with POLR3D.[8]

Notes and references

1. ENSG00000058600 GRCh38: Ensembl release 89: ENSG00000284282, ENSG00000058600 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030880 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
6. Dong Z, Bell LR (Nov 1999). "SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal". Gene. 237 (2): 421–428. doi:10.1016/S0378-1119(99)00303-0. PMID 10521666.
7. "Entrez Gene: POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)".
8. Hu, Ping; Wu Si; Sun Yuling; Yuan Chih-Chi; Kobayashi Ryuji; Myers Michael P; Nouria Hernandez (Nov 2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. United States. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. ISSN 0270-7306. PMC 134740. PMID 12391170.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–1147. PMID 1403646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits". Mol. Cell. Biol. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.