POLR2G

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.[5][6]

POLR2G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDsOMIM: 602013 MGI: 1914960 HomoloGene: 2019 GeneCards: POLR2G
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.3Start62,761,565 bp[1]
End62,766,710 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5436

67710

Ensembl

ENSG00000168002

ENSMUSG00000071662

UniProt

P62487

P62488

RefSeq (mRNA)

NM_002696

NM_026329

RefSeq (protein)

NP_002687

NP_080605

Location (UCSC)Chr 11: 62.76 – 62.77 MbChr 19: 8.79 – 8.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.[7]

Interactions

POLR2G has been shown to interact with TAF15,[8] POLR2C,[9] POLR2H[9] and POLR2E.[9]

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References

  1. GRCh38: Ensembl release 89: ENSG00000168002 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071662 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC 301239. PMID 7579693.
  6. Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID 9256063.
  7. "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G".
  8. Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.
  9. Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Further reading

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