POLDIP3

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[5][6]

POLDIP3
Identifiers
Aliases	POLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDs	OMIM: 611520 MGI: 1921076 HomoloGene: 13007 GeneCards: POLDIP3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 42,583,721 bp[1] End 42,614,962 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,125,976 bp[2] End 83,149,384 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • RNA binding • GO:0032403 macromolecular complex binding Cellular component • exon-exon junction complex • transcription export complex • cell nucleus • nuclear speck • cytoplasm • cytosol • nucleoplasm • cytoplasmic ribonucleoprotein granule Biological process • poly(A)+ mRNA export from nucleus • mRNA transport • regulation of translation • positive regulation of translation • termination of RNA polymerase II transcription • mRNA 3'-end processing • RNA export from nucleus • mRNA export from nucleus • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84271	73826
Ensembl	ENSG00000100227	ENSMUSG00000041815
UniProt	Q9BY77 Q8WUT1	Q8BG81
RefSeq (mRNA)	NM_001278657 NM_032311 NM_178136 NM_001363052	NM_178627 NM_001347082
RefSeq (protein)	NP_001265586 NP_115687 NP_835237 NP_001349981	NP_001334011 NP_848742
Location (UCSC)	Chr 22: 42.58 – 42.61 Mb	Chr 15: 83.13 – 83.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[6]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100227 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041815 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
6. "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
7. Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. England. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. CiteSeerX 10.1.1.321.2497. doi:10.1093/dnares/8.1.1. PMID 11258795.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. PMID 15341740.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth". FEBS J. 273 (20): 4728–41. doi:10.1111/j.1742-4658.2006.05477.x. PMID 16984396.