PLXNB3

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.[5][6]

PLXNB3
Identifiers
Aliases	PLXNB3, PLEXB3, PLEXR, PLXN6, plexin B3
External IDs	OMIM: 300214 MGI: 2154240 HomoloGene: 68468 GeneCards: PLXNB3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,764,196 bp[1] End 153,779,346 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 73,757,090 bp[2] End 73,772,514 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • semaphorin receptor activity • Rho GDP-dissociation inhibitor binding • protein domain specific binding • GO:0001948 protein binding • protein binding involved in cell-cell adhesion Cellular component • integral component of membrane • membrane • cell membrane • cell surface • semaphorin receptor complex • integral component of plasma membrane Biological process • negative regulation of cell adhesion • positive regulation of endothelial cell proliferation • positive regulation of axonogenesis • nervous system development • negative regulation of cell migration • GO:0034259 negative regulation of GTPase activity • regulation of cell shape • cell chemotaxis • positive chemotaxis • semaphorin-plexin signaling pathway • signal transduction • negative regulation of lamellipodium assembly • positive regulation of neuron projection development • homophilic cell adhesion via plasma membrane adhesion molecules • axon extension • regulation of cell migration • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5365	140571
Ensembl	ENSG00000198753	ENSMUSG00000031385
UniProt	Q9ULL4	Q9QY40
RefSeq (mRNA)	NM_005393 NM_001163257	NM_019587
RefSeq (protein)	NP_001156729 NP_005384	NP_062533
Location (UCSC)	Chr X: 153.76 – 153.78 Mb	Chr X: 73.76 – 73.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PLXNB3 has been shown to interact with ARHGEF11.[7][8]

Model organisms

Model organisms have been used in the study of PLXNB3 function. A conditional knockout mouse line called Plxnb3^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.[9] Male and female animals underwent a standardized phenotypic screen[10] to determine the effects of deletion.[11][12][13][14] Additional screens performed: - In-depth immunological phenotyping[15]

Plxnb3 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[10][15]{
Peripheral blood leukocytes 6 Weeks	Normal
Insulin	Normal
Haematology 6 Weeks	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Abnormal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References

1. GRCh38: Ensembl release 89: ENSG00000198753 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031385 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
6. "Entrez Gene: PLXNB3 plexin B3".
7. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
8. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
10. "International Mouse Phenotyping Consortium".
11. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
12. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
13. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
14. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
15. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

• Sandoval N, Bauer D, Brenner V, Coy JF, Drescher B, Kioschis P, Korn B, Nyakatura G, Poustka A, Reichwald K, Rosenthal A, Platzer M (Jul 1996). "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". Genomics. 35 (2): 383–5. doi:10.1006/geno.1996.0373. PMID 8661155.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (Aug 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (Jul 2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L (Jul 2004). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Reports. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
• Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience. 6: 53. doi:10.1186/1471-2202-6-53. PMC 1215486. PMID 16122393.
• Rujescu D, Meisenzahl EM, Krejcova S, Giegling I, Zetzsche T, Reiser M, Born CM, Möller HJ, Veske A, Gal A, Finckh U (Feb 2007). "Plexin B3 is genetically associated with verbal performance and white matter volume in human brain". Molecular Psychiatry. 12 (2): 190–4, 115. doi:10.1038/sj.mp.4001903. PMID 17033634.