PLXNA3

Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene.[5][6][7]

PLXNA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IG3
Identifiers
Aliases	PLXNA3, 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6, plexin A3
External IDs	OMIM: 300022 MGI: 107683 HomoloGene: 7481 GeneCards: PLXNA3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,458,281 bp[1] End 154,477,779 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 38.0 cM Start 74,329,066 bp[2] End 74,344,689 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transmembrane signaling receptor activity • semaphorin receptor activity Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • cell membrane • semaphorin receptor complex • cell junction • cell nucleus • integral component of plasma membrane Biological process • regulation of axon extension involved in axon guidance • negative chemotaxis • negative regulation of axon extension involved in axon guidance • neuron projection extension • multicellular organism development • neuron projection guidance • branchiomotor neuron axon guidance • positive regulation of cytoskeleton organization • pyramidal neuron development • facial nerve structural organization • hippocampus development • trigeminal nerve structural organization • semaphorin-plexin signaling pathway • signal transduction • axon guidance • semaphorin-plexin signaling pathway involved in axon guidance • negative regulation of cell adhesion • regulation of cell shape • regulation of cell migration • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of axonogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55558	18846
Ensembl	ENSG00000130827	ENSMUSG00000031398
UniProt	P51805	P70208
RefSeq (mRNA)	NM_017514	NM_008883 NM_001358129
RefSeq (protein)	NP_059984	NP_032909 NP_001345058
Location (UCSC)	Chr X: 154.46 – 154.48 Mb	Chr X: 74.33 – 74.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130827 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031398 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bione S, Tamanini F, Maestrini E, Tribioli C, Poustka A, Torri G, Rivella S, Toniolo D (Jan 1994). "Transcriptional organization of a 450-kb region of the human X chromosome in Xq28". Proc Natl Acad Sci U S A. 90 (23): 10977–81. doi:10.1073/pnas.90.23.10977. PMC 47904. PMID 8248200.
6. Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (Jun 1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
7. "Entrez Gene: PLXNA3 plexin A3".

Further reading

• Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum. Mol. Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID 8281148.
• Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
• Kameyama T, Murakami Y, Suto F, Kawakami A, Takagi S, Hirata T, Fujisawa H (1996). "Identification of plexin family molecules in mice". Biochem. Biophys. Res. Commun. 226 (2): 396–402. doi:10.1006/bbrc.1996.1367. PMID 8806646.
• Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.